Document Detail

Neural response to the second stimulus associated with poor speed discrimination performance in schizophrenia.
MedLine Citation:
PMID:  22092174     Owner:  NLM     Status:  Publisher    
Visual motion processing is compromised in schizophrenia (SZ), but it is uncertain what neural deviations account for their motion analysis abnormalities. Neural activations were measured with dense-array electroencephalography while 14 medicated SZ and 14 healthy persons performed a paired-stimuli forced choice speed discrimination task. SZ had (a) worse-at-speed discrimination, replicating previous findings, (b) normal early extrastriate neural activity (N1) to both motion stimuli, (c) reduced later extrastriate activity (P2) specifically to the second stimulus, and (d) following P2, an enhanced later N2 over parietal cortex. Stronger P2 and N2 responses were associated with better speed discrimination performance across groups. These findings indicate that the neural correlates of poor motion analysis in SZ may not be an early visual analysis abnormality but a problem with efficient use of speed information later in cognitive processing.
Jun Wang; Karen R Dobkins; Jennifer E McDowell; Brett A Clementz
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-10-6
Journal Detail:
Title:  Psychophysiology     Volume:  -     ISSN:  1540-5958     ISO Abbreviation:  -     Publication Date:  2011 Oct 
Date Detail:
Created Date:  2011-11-18     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0142657     Medline TA:  Psychophysiology     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2011 Society for Psychophysiological Research.
Department of Psychiatry, Autism Center, University of Texas Southwestern Medical Center, Dallas, Texas.
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