Document Detail

Neural response to the behaviorally relevant absence of anticipated outcomes and the presentation of potentially harmful stimuli: A human fMRI study.
MedLine Citation:
PMID:  20060966     Owner:  NLM     Status:  In-Process    
Adaptive behavior requires the ability to react to potentially harmful stimuli, characterized by high negative inherent emotional salience (iES) (e.g., spiders, snakes), and to the unexpected non-occurrence of anticipated events. When presented simultaneously, threatening stimuli and unexpected absence of anticipated outcomes induce distinct electrocortical responses in different time periods. In this study, we used fMRI to test whether processing of the absence of anticipated outcomes (prediction errors) was anatomically dissociated from the processing of iES or whether iES simply modulated activity of areas processing the non-occurrence of anticipated outcomes. Participants saw two alternating pairs of faces and indicated for each pair which one would have a declared target stimulus on its nose. Depending on the condition, the target stimulus was either a spider (high iES stimulus) or a disk (low iES stimulus). The target stimulus switched to the other face after several consecutive correct responses, with the switch being indicated by the appearance of the alternative stimulus (disk when the spider was the declared target; spider when the disk was the declared target). We found that the spider induced stronger activation in visual areas than the disk. By contrast, the absence of anticipated outcomes specifically activated the orbitofrontal cortex (OFC), irrespective of the iES of the outcome stimulus. The findings support a generic role of the OFC in outcome monitoring.
Louis Nahum; Stéphane R Simon; David Sander; François Lazeyras; Armin Schnider
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2009-12-22
Journal Detail:
Title:  Cortex; a journal devoted to the study of the nervous system and behavior     Volume:  47     ISSN:  1973-8102     ISO Abbreviation:  Cortex     Publication Date:  2011 Feb 
Date Detail:
Created Date:  2010-12-20     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0100725     Medline TA:  Cortex     Country:  Italy    
Other Details:
Languages:  eng     Pagination:  191-201     Citation Subset:  IM    
Copyright Information:
Copyright © 2009 Elsevier Srl. All rights reserved.
Laboratory of Cognitive Neurorehabilitation, Division of Neurorehabilitation, Department of Clinical Neurosciences, University Hospitals and University of Geneva, Switzerland.
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