| Neural representations of relevant and irrelevant features in perceptual decision making. | |
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MedLine Citation:
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PMID: 21106817 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Although perceptual decision making activates a network of brain areas involved in sensory, integrative, and motor functions, circuit activity can clearly be modulated by factors beyond the stimulus. Of particular interest is to understand how the network is modulated by top-down factors such as attention. Here, we demonstrate in a motion coherence task that selective attention produces marked changes in the blood oxygen level-dependent (BOLD) response in a subset of regions within a human perceptual decision-making circuit. Specifically, when motion is attended, the BOLD response decreases with increasing motion coherence in many regions, including the motion-sensitive area MT+, the intraparietal sulcus, and the inferior frontal sulcus. However, when motion is ignored, the negative parametric response in a subset of this circuit becomes positive. Through both modeling and connectivity analyses, we demonstrate that this inversion both reflects a top-down influence and segregates attentional from accumulation regions, thereby permitting us to further delineate the contributions of different regions to the perceptual decision. |
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Authors:
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Andrew S Kayser; Drew T Erickson; Bradley R Buchsbaum; Mark D'Esposito |
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Publication Detail:
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Type: Comparative Study; Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: The Journal of neuroscience : the official journal of the Society for Neuroscience Volume: 30 ISSN: 1529-2401 ISO Abbreviation: J. Neurosci. Publication Date: 2010 Nov |
Date Detail:
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Created Date: 2010-11-25 Completed Date: 2010-12-27 Revised Date: 2011-08-01 |
Medline Journal Info:
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Nlm Unique ID: 8102140 Medline TA: J Neurosci Country: United States |
Other Details:
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Languages: eng Pagination: 15778-89 Citation Subset: IM |
Affiliation:
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Department of Neurology, University of California, San Francisco, Emeryville, CA 94608, USA. akayser@gallo.ucsf.edu |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Color Perception / physiology* Decision Making / physiology* Female Humans Magnetic Resonance Imaging / methods Male Motion Perception / physiology* Nerve Net / physiology* Photic Stimulation / methods Psychomotor Performance / physiology Reaction Time / physiology |
| Grant Support | |
ID/Acronym/Agency:
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MH-63901/MH/NIMH NIH HHS; NS-40813/NS/NINDS NIH HHS; P01 NS040813-06/NS/NINDS NIH HHS; R01 MH063901-01/MH/NIMH NIH HHS |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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