Document Detail


Neural repetitive firing: modifications of the Hodgkin-Huxley axon suggested by experimental results from crustacean axons.
MedLine Citation:
PMID:  856318     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The Hodgkin-Huxley equations for space-clamped squid axon (18 degrees C) have been modified to approximate voltage clamp data from repetitive-firing crustacean walking leg axons and activity in response to constant current stimulation has been computed. The m infinity and h infinity parameters of the sodium conductance system were shifted along the voltage axis in opposite directions so that their relative overlap was increased approximately 7 mV. Time constants tau m and tau h, were moved in a similar manner. Voltage-dependent parameters of delayed potassium conductance, n infinity and tau n, were shifted 4.3 mV in the positive direction and tau n was uniformly increased by a factor of 2. Leakage conductance and capacitance were unchanged. Repetitive activity of this modified circuit was qualitatively similar to that of the standard model. A fifth branch was added to the circuit representing a transient potassium conductance system present in the repetitive walking leg axons and in other repetitive neurons. This model, with various parameter choices, fired repetitively down to approximately 2 spikes/s and up to 350/s. The frequency vs. stimulus current plot could be fit well by a straight line over a decade of the low frequency range and the general appearance of the spike trains was similar to that of other repetitive neurons. Stimulus intensities were of the same order as those which produce repetitive activity in the standard Hodgkin-Huxley axon. The repetitive firing rate and first spike latency (utilization time) were found to be most strongly influenced by the inactivation time constant of the transient potassium conductance (tau b), the delayed potassium conductance (tau n), and the value of leakage conductance (gL). The model presents a mechanism by which stable low frequency discharge can be generated by millisecond-order membrane conductance changes.
Authors:
J A Connor; D Walter; R McKown
Related Documents :
6251178 - On- versus off-responses of raccoon glabrous skin rapidly adapting cutaneous mechanorec...
21642648 - Acupuncture sensation during ultrasound guided acupuncture needling.
8809788 - Activity-dependent slowing of conduction velocity provides a method for identifying dif...
24287308 - Measuring and using light in the melanopsin age.
23005288 - Sub-rayleigh lithography using high flux loss-resistant entangled states of light.
17360948 - Immunoglobulin light chains generate hydrogen peroxide.
Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Biophysical journal     Volume:  18     ISSN:  0006-3495     ISO Abbreviation:  Biophys. J.     Publication Date:  1977 Apr 
Date Detail:
Created Date:  1977-06-11     Completed Date:  1977-06-11     Revised Date:  2013-06-12    
Medline Journal Info:
Nlm Unique ID:  0370626     Medline TA:  Biophys J     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  81-102     Citation Subset:  IM    
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Action Potentials*
Animals
Axons / physiology*
Brachyura
Electric Conductivity
Models, Neurological*
Potassium / physiology
Sodium / physiology
Chemical
Reg. No./Substance:
7440-09-7/Potassium; 7440-23-5/Sodium
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Unstirred layer effects on calculations of the potential difference across an ion exchange membrane.
Next Document:  Three steady state situation in an open chemical reaction system I.