Document Detail

Neural progenitor nuclei IN motion.
MedLine Citation:
PMID:  20869589     Owner:  NLM     Status:  MEDLINE    
Interkinetic nuclear migration (INM), the movement of neuroepithelial and radial glial cell nuclei along the apical-basal axis in concert with the cell cycle, underlies the pseudostratification of the ventricular zone (VZ). Recent studies provide insight into the molecular mechanisms of INM and its effects on neural progenitor cell fate determination. Moreover, INM not only has a key role in increasing the VZ progenitor pool, but also may have set the stage for the evolution of subventricular zone progenitors implicated in cortical expansion.
Elena Taverna; Wieland B Huttner
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  Neuron     Volume:  67     ISSN:  1097-4199     ISO Abbreviation:  Neuron     Publication Date:  2010 Sep 
Date Detail:
Created Date:  2010-09-27     Completed Date:  2010-10-15     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8809320     Medline TA:  Neuron     Country:  United States    
Other Details:
Languages:  eng     Pagination:  906-14     Citation Subset:  IM    
Copyright Information:
Copyright © 2010 Elsevier Inc. All rights reserved.
Max Planck Institute of Molecular Cell Biology and Genetics, Dresden, Germany.
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MeSH Terms
Actomyosin / metabolism
Cell Cycle / physiology
Cell Differentiation / physiology*
Cell Nucleus / physiology*,  ultrastructure
Cell Polarity / physiology
Centrosome / physiology,  ultrastructure
Cerebral Ventricles / cytology
Microtubules / metabolism
Neurons / physiology,  ultrastructure*
Stem Cells / physiology*,  ultrastructure
Reg. No./Substance:

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