Document Detail

Neural precursor cell lines promote neurite branching.
MedLine Citation:
PMID:  19116829     Owner:  NLM     Status:  MEDLINE    
Schwann cells and primary progenitor cells improve regeneration across peripheral nerve defects. This study examined the impact of immortalized neural precursor cells on regeneration of rat nerve defects. Across 10-mm gaps, neuromas formed without neural cables with C17.2- or RN33B-transplanted cells, but neural cables formed across 5-mm gaps seeded with RN33B cells. In vitro, dorsal root ganglia neurites elongated across Schwann and RN33B cells; RN33B cells induced neurite branching with shorter total outgrowth. Neural cable formation in vivo was likely determined by the balance of guidance and branch-inducing factors secreted by Schwann and transplanted precursor cells.
Craig M Neville; Albert Y Huang; Jeffrey Y Shyu; Evan Y Snyder; Tessa A Hadlock; Cathryn A Sundback
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The International journal of neuroscience     Volume:  119     ISSN:  1563-5279     ISO Abbreviation:  Int. J. Neurosci.     Publication Date:  2009  
Date Detail:
Created Date:  2008-12-31     Completed Date:  2009-04-09     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0270707     Medline TA:  Int J Neurosci     Country:  United States    
Other Details:
Languages:  eng     Pagination:  15-39     Citation Subset:  IM    
Center for Regenerative Medicine, Massachusetts General Hospital Harvard Medical School, Boston, Massachusetts 02114, USA.
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MeSH Terms
Cell Differentiation / physiology
Cell Line
Cell Line, Transformed
Cells, Cultured
Chick Embryo
Collagen / pharmacology
Drug Combinations
Ganglia, Spinal / cytology,  physiology
Growth Cones / physiology*,  ultrastructure
Laminin / pharmacology
Nerve Regeneration / physiology*
Neurites / physiology,  ultrastructure
Neurogenesis / physiology
Peripheral Nerves / cytology,  physiology
Proteoglycans / pharmacology
Rats, Inbred F344
Schwann Cells / cytology,  physiology*,  transplantation*
Sciatic Neuropathy / therapy
Sensory Receptor Cells / cytology,  physiology
Stem Cell Transplantation / methods*
Stem Cells / cytology,  physiology*
Reg. No./Substance:
0/Drug Combinations; 0/Laminin; 0/Proteoglycans; 119978-18-6/matrigel; 9007-34-5/Collagen

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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