Document Detail


Neural precursor cell lines promote neurite branching.
MedLine Citation:
PMID:  19116829     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Schwann cells and primary progenitor cells improve regeneration across peripheral nerve defects. This study examined the impact of immortalized neural precursor cells on regeneration of rat nerve defects. Across 10-mm gaps, neuromas formed without neural cables with C17.2- or RN33B-transplanted cells, but neural cables formed across 5-mm gaps seeded with RN33B cells. In vitro, dorsal root ganglia neurites elongated across Schwann and RN33B cells; RN33B cells induced neurite branching with shorter total outgrowth. Neural cable formation in vivo was likely determined by the balance of guidance and branch-inducing factors secreted by Schwann and transplanted precursor cells.
Authors:
Craig M Neville; Albert Y Huang; Jeffrey Y Shyu; Evan Y Snyder; Tessa A Hadlock; Cathryn A Sundback
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The International journal of neuroscience     Volume:  119     ISSN:  1563-5279     ISO Abbreviation:  Int. J. Neurosci.     Publication Date:  2009  
Date Detail:
Created Date:  2008-12-31     Completed Date:  2009-04-09     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0270707     Medline TA:  Int J Neurosci     Country:  United States    
Other Details:
Languages:  eng     Pagination:  15-39     Citation Subset:  IM    
Affiliation:
Center for Regenerative Medicine, Massachusetts General Hospital Harvard Medical School, Boston, Massachusetts 02114, USA.
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MeSH Terms
Descriptor/Qualifier:
Animals
Cell Differentiation / physiology
Cell Line
Cell Line, Transformed
Cells, Cultured
Chick Embryo
Collagen / pharmacology
Drug Combinations
Ganglia, Spinal / cytology,  physiology
Growth Cones / physiology*,  ultrastructure
Laminin / pharmacology
Male
Nerve Regeneration / physiology*
Neurites / physiology,  ultrastructure
Neurogenesis / physiology
Peripheral Nerves / cytology,  physiology
Proteoglycans / pharmacology
Rats
Rats, Inbred F344
Schwann Cells / cytology,  physiology*,  transplantation*
Sciatic Neuropathy / therapy
Sensory Receptor Cells / cytology,  physiology
Stem Cell Transplantation / methods*
Stem Cells / cytology,  physiology*
Chemical
Reg. No./Substance:
0/Drug Combinations; 0/Laminin; 0/Proteoglycans; 119978-18-6/matrigel; 9007-34-5/Collagen

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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