| Neural population partitioning and a concurrent brain-machine interface for sequential motor function. | |
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MedLine Citation:
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PMID: 23143511 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Although brain-machine interfaces (BMIs) have focused largely on performing single-targeted movements, many natural tasks involve planning a complete sequence of such movements before execution. For these tasks, a BMI that can concurrently decode the full planned sequence before its execution may also consider the higher-level goal of the task to reformulate and perform it more effectively. Using population-wide modeling, we discovered two distinct subpopulations of neurons in the rhesus monkey premotor cortex that allow two planned targets of a sequential movement to be simultaneously held in working memory without degradation. Such marked stability occurred because each subpopulation encoded either only currently held or only newly added target information irrespective of the exact sequence. On the basis of these findings, we developed a BMI that concurrently decodes a full motor sequence in advance of movement and can then accurately execute it as desired. |
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Authors:
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Maryam M Shanechi; Rollin C Hu; Marissa Powers; Gregory W Wornell; Emery N Brown; Ziv M Williams |
Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't Date: 2012-11-11 |
Journal Detail:
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Title: Nature neuroscience Volume: 15 ISSN: 1546-1726 ISO Abbreviation: Nat. Neurosci. Publication Date: 2012 Dec |
Date Detail:
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Created Date: 2012-11-28 Completed Date: 2013-01-29 Revised Date: 2013-05-13 |
Medline Journal Info:
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Nlm Unique ID: 9809671 Medline TA: Nat Neurosci Country: United States |
Other Details:
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Languages: eng Pagination: 1715-22 Citation Subset: IM |
Affiliation:
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Department of Electrical Engineering and Computer Science, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Action Potentials
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physiology* Animals Brain-Computer Interfaces* Macaca mulatta Male Motor Cortex / cytology*, physiology* Neurons / cytology, physiology* Photic Stimulation / methods Psychomotor Performance / physiology* Random Allocation Reaction Time / physiology* |
| Grant Support | |
ID/Acronym/Agency:
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5R01-HD059852/HD/NICHD NIH HHS; DP1 OD003646/OD/NIH HHS; DP1 OD003646/OD/NIH HHS |
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