| Neural mechanisms underlying spatial realignment during adaptation to optical wedge prisms. | |
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MedLine Citation:
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PMID: 20457170 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Visuomotor adaptation to a shift in visual input produced by prismatic lenses is an example of dynamic sensory-motor plasticity within the brain. Prism adaptation is readily induced in healthy individuals, and is thought to reflect the brain's ability to compensate for drifts in spatial calibration between different sensory systems. The neural correlate of this form of functional plasticity is largely unknown, although current models predict the involvement of parieto-cerebellar circuits. Recent studies that have employed event-related functional magnetic resonance imaging (fMRI) to identify brain regions associated with prism adaptation have discovered patterns of parietal and cerebellar modulation as participants corrected their visuomotor errors during the early part of adaptation. However, the role of these regions in the later stage of adaptation, when 'spatial realignment' or true adaptation is predicted to occur, remains unclear. Here, we used fMRI to quantify the distinctive patterns of parieto-cerebellar activity as visuomotor adaptation develops. We directly contrasted activation patterns during the initial error correction phase of visuomotor adaptation with that during the later spatial realignment phase, and found significant recruitment of the parieto-cerebellar network--with activations in the right inferior parietal lobe and the right posterior cerebellum. These findings provide the first evidence of both cerebellar and parietal involvement during the spatial realignment phase of prism adaptation. |
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Authors:
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Heidi L Chapman; Ranmalee Eramudugolla; Maria Gavrilescu; Mark W Strudwick; Andrea Loftus; Ross Cunnington; Jason B Mattingley |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2010-05-08 |
Journal Detail:
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Title: Neuropsychologia Volume: 48 ISSN: 1873-3514 ISO Abbreviation: Neuropsychologia Publication Date: 2010 Jul |
Date Detail:
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Created Date: 2010-07-12 Completed Date: 2010-10-20 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0020713 Medline TA: Neuropsychologia Country: England |
Other Details:
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Languages: eng Pagination: 2595-601 Citation Subset: IM |
Copyright Information:
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Copyright (c) 2010 Elsevier Ltd. All rights reserved. |
Affiliation:
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School of Psychology, University of Birmingham, United Kingdom. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adaptation, Ocular
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physiology* Adult Analysis of Variance Brain / blood supply, physiology* Brain Mapping* Functional Laterality / physiology Humans Image Processing, Computer-Assisted / methods Lenses* Magnetic Resonance Imaging / methods Male Oxygen / blood Photic Stimulation / methods Psychomotor Performance Space Perception / physiology* Vision, Ocular / physiology* Young Adult |
| Chemical | |
Reg. No./Substance:
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7782-44-7/Oxygen |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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