Document Detail

Neural mechanisms underlying obesity and drug addiction.
MedLine Citation:
PMID:  17292426     Owner:  NLM     Status:  MEDLINE    
Increasing rates of obesity have alarmed health officials and prompted much public dialogue. While the factors leading to obesity are numerous, an inability to control intake of freely available food is central to the problem. In order to understand this, we need to better define the mechanisms by which the brain regulates food intake, and why it is often difficult to control consumption. From this point of view, it seems valuable to consider the commonalities between food intake and drug abuse. While research in the two fields has historically emphasized different neural substrates, recent data have increased interest in better defining elements that may underlie both drug addiction and obesity. Here we discuss some of these shared elements with an emphasis on emerging areas of research that better define common mechanisms leading to overconsumption.
Richard Trinko; Robert M Sears; Douglas J Guarnieri; Ralph J DiLeone
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Publication Detail:
Type:  Journal Article; Review     Date:  2007-01-16
Journal Detail:
Title:  Physiology & behavior     Volume:  91     ISSN:  0031-9384     ISO Abbreviation:  Physiol. Behav.     Publication Date:  2007 Aug 
Date Detail:
Created Date:  2007-08-20     Completed Date:  2007-11-28     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0151504     Medline TA:  Physiol Behav     Country:  United States    
Other Details:
Languages:  eng     Pagination:  499-505     Citation Subset:  IM    
Department of Psychiatry, Yale University School of Medicine, New Haven, CT 06519, USA.
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MeSH Terms
Behavior, Addictive / physiopathology*,  psychology
Brain / physiopathology
Obesity / physiopathology*,  psychology
Substance-Related Disorders / physiopathology*,  psychology

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