Document Detail


Neural mechanisms in cardiac arrhythmias associated with epileptogenic activity: the effect of phenobarbital in the cat.
MedLine Citation:
PMID:  6727547     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Sudden unexplained death accounts for 5-17% of mortality in epileptic persons; autonomic dysfunction is thought to be a contributing factor. This paper describes the effect of phenobarbital (PB) pretreatment (20 mg/kg, i.v.) one hour prior to pentylenetetrazol (PTZ) 10, 20, 50, 100, 200, and 2000 mg/kg, i.v. given at ten minute intervals on autonomic parameters in the cat. PB depressed heart rate, blood pressure, and postganglionic cardiac sympathetic neural discharge, but did not significantly alter vagal discharge. PB shifted the peak duration of interictal activity from a lower to a higher dose of PTZ without affecting the average duration across doses. PB also significantly diminished the increases in heart rate and blood pressure induced by PTZ but altered neither the occurrence of arrhythmias nor the changes in cardiac autonomic neural discharge. Thus, PB appears to prevent only some forms of autonomic dysfunction associated with epileptogenic activity in this model.
Authors:
C M Lathers; P L Schraeder; S B Carnel
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Life sciences     Volume:  34     ISSN:  0024-3205     ISO Abbreviation:  Life Sci.     Publication Date:  1984 May 
Date Detail:
Created Date:  1984-07-09     Completed Date:  1984-07-09     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0375521     Medline TA:  Life Sci     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  1919-36     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Animals
Arrhythmias, Cardiac / etiology*
Autonomic Nervous System / physiopathology*
Blood Pressure / drug effects
Cats
Disease Models, Animal
Electrocardiography
Electroencephalography
Epilepsy / physiopathology*
Heart / innervation
Heart Rate / drug effects
Lung / pathology
Pentylenetetrazole
Phenobarbital / pharmacology*
Grant Support
ID/Acronym/Agency:
BRSGRR-04518/RS/DRS NIH HHS
Chemical
Reg. No./Substance:
50-06-6/Phenobarbital; 54-95-5/Pentylenetetrazole

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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