| Neural mechanisms in Williams syndrome: a unique window to genetic influences on cognition and behaviour. | |
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MedLine Citation:
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PMID: 16760918 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Williams syndrome, a rare disorder caused by hemizygous microdeletion of about 28 genes on chromosome 7q11.23, has long intrigued neuroscientists with its unique combination of striking behavioural abnormalities, such as hypersociability, and characteristic neurocognitive profile. Williams syndrome, therefore, raises fundamental questions about the neural mechanisms of social behaviour, the modularity of mind and brain development, and provides a privileged setting to understand genetic influences on complex brain functions in a 'bottom-up' way. We review recent advances in uncovering the functional and structural neural substrates of Williams syndrome that provide an emerging understanding of how these are related to dissociable genetic contributions characterized both in special participant populations and animal models. |
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Authors:
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Andreas Meyer-Lindenberg; Carolyn B Mervis; Karen Faith Berman |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, N.I.H., Intramural; Review |
Journal Detail:
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Title: Nature reviews. Neuroscience Volume: 7 ISSN: 1471-003X ISO Abbreviation: Nat. Rev. Neurosci. Publication Date: 2006 May |
Date Detail:
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Created Date: 2006-06-08 Completed Date: 2006-07-13 Revised Date: 2012-05-28 |
Medline Journal Info:
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Nlm Unique ID: 100962781 Medline TA: Nat Rev Neurosci Country: England |
Other Details:
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Languages: eng Pagination: 380-93 Citation Subset: IM |
Affiliation:
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Unit for Systems Neuroscience in Psychiatry, National Institute of Mental Health, NIH, DHHS, 9000 Rockville Pike, Bethesda, Maryland 20892-1365, USA. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Behavior / physiology* Brain / blood supply, pathology, physiopathology* Cognition / physiology* Humans Image Processing, Computer-Assisted / methods Magnetic Resonance Imaging / methods Social Behavior Williams Syndrome* / genetics, pathology, physiopathology |
| Grant Support | |
ID/Acronym/Agency:
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R01 NS035102/NS/NINDS NIH HHS |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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