Document Detail

Neural mechanism of residual inhibition of tinnitus in cochlear implant users.
MedLine Citation:
PMID:  16189467     Owner:  NLM     Status:  MEDLINE    
Residual inhibition is a transient suppression of tinnitus after auditory stimulation has stopped. We used positron emission tomography to study brain regions underlying residual inhibition in three tinnitus patients with cochlear implants and six normal hearing controls. Regional cerebral blood flow was measured and compared under two conditions: with tinnitus and during the residual inhibition of tinnitus. The right anterior middle and superior temporal gyri (Brodmann areas 21 and 38) were activated during residual inhibition, while the right cerebellum was activated during tinnitus perception in the tinnitus patients. No significant activation was observed in the normal controls. Our results suggest that tinnitus and residual inhibition are related to cortical networks of auditory higher-order processing, memory and attention.
Yasuhiro Osaki; Hiroshi Nishimura; Masashi Takasawa; Masao Imaizumi; Takayuki Kawashima; Takako Iwaki; Naohiko Oku; Kazuo Hashikawa; Katsumi Doi; Tsunehiko Nishimura; Jun Hatazawa; Takeshi Kubo
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Publication Detail:
Type:  Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Neuroreport     Volume:  16     ISSN:  0959-4965     ISO Abbreviation:  Neuroreport     Publication Date:  2005 Oct 
Date Detail:
Created Date:  2005-09-28     Completed Date:  2005-12-01     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9100935     Medline TA:  Neuroreport     Country:  England    
Other Details:
Languages:  eng     Pagination:  1625-8     Citation Subset:  IM    
Department of Otorhinolaryngology and Sensory Organ Surgery, Osaka University Graduate School of Medicine, Japan.
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MeSH Terms
Cerebellum / blood supply,  physiology,  radionuclide imaging
Cerebrovascular Circulation / physiology
Cochlear Implants*
Deafness / physiopathology
Positron-Emission Tomography
Temporal Lobe / blood supply,  physiology,  radionuclide imaging
Tinnitus / physiopathology*,  radionuclide imaging

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