Document Detail

Neural mechanism of hypertension by nitric oxide synthase inhibitor in dogs.
MedLine Citation:
PMID:  7678095     Owner:  NLM     Status:  MEDLINE    
This study aimed to determine the mechanism of hypertension associated with nitric oxide synthase inhibition. Intravenous injections of NG-nitro-L-arginine, a nitric oxide synthase inhibitor, produced a sustained increase in systemic blood pressure and a decrease in heart rate in anesthetized dogs, whereas NG-nitro-D-arginine had no effect. L-Arginine reversed the pressor response. NG-Nitro-L-arginine-induced hypertension was markedly attenuated or abolished by treatment with hexamethonium; this inhibition was still observed when the blood pressure fall caused by the ganglionic blocking agent was compensated by continuous infusion of angiotensin II. In dogs treated with phentolamine in a dose sufficient to lower blood pressure to the level similar to that elicited by hexamethonium and to suppress the pressor response to norepinephrine, the hypertensive effect of NG-nitro-L-arginine was not attenuated. We conclude that hypertension caused by the nitric oxide synthase inhibitor is associated with an elimination of nitroxidergic neural function rather than an impairment of the basal release of nitric oxide from the endothelium.
N Toda; Y Kitamura; T Okamura
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Hypertension     Volume:  21     ISSN:  0194-911X     ISO Abbreviation:  Hypertension     Publication Date:  1993 Jan 
Date Detail:
Created Date:  1993-02-01     Completed Date:  1993-02-01     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7906255     Medline TA:  Hypertension     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  3-8     Citation Subset:  IM    
Department of Pharmacology, Shiga University of Medical Sciences, Ohtsu, Japan.
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MeSH Terms
Amino Acid Oxidoreductases / antagonists & inhibitors*
Arginine / analogs & derivatives*,  pharmacology
Blood Pressure / drug effects
Heart Rate / drug effects
Hexamethonium Compounds / pharmacology
Hypertension / physiopathology*
Nitric Oxide Synthase
Phentolamine / pharmacology
Reg. No./Substance:
0/Hexamethonium Compounds; 2149-70-4/Nitroarginine; 50-60-2/Phentolamine; 60-26-4/Hexamethonium; 74-79-3/Arginine; EC Oxide Synthase; EC 1.4.-/Amino Acid Oxidoreductases

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