Document Detail


Neural lesions in the rat and their relationship to EEG delta activity following seizures induced by the nerve agent soman.
MedLine Citation:
PMID:  9621344     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
This study describes the neural structures damaged following exposure to the nerve agent soman, shows there are time-dependent differences in the extent of damage in certain structures, and relates seizure-induced increases in delta band (0-3.5 Hz) electroencephalographic (EEG) activity with severity of subsequent neuropathology. Rats, instrumented to record cortical EEG activity, were pretreated with the oxime HI-6 (125 mg/kg, i.p.) and then challenged with soman (180 ug/kg, s.c.). All animals developed continuous epileptiform seizures that lasted in excess of 4 hr. Groups of animals were perfused 1, 3, 10 or 30 days following exposure. Paraffin-embedded brains were stained with hematoxylin and eosin; thirty-four neural structures were examined and scored for neural damage. All cortical areas sustained damage, with piriform and perirhinal cortices exhibiting the most severe. Subcortical limbic areas (amygdala, amygdala-piriform transition zone, hippocampus, claustrum) and various thalamic nuclei were most consistently and severely damaged in all animals regardless of survival time. Brainstem structures, cerebellum, spinal cord, and other motor output nuclei were never damaged. It was found that some structures were rated as more severely damaged when evaluated at shorter survival times. Severity of neural damage was related to high levels of EEG delta power recorded 24 hr after exposure; power during the acute seizure or 24 hr body weight loss did not predict lesion severity. Sections between AP -0.8 to -4.8 contain cortical and subcortical structures that can be readily and reproducibly evaluated for brain damage.
Authors:
J H McDonough; T R Clark; T W Slone; D Zoeffel; K Brown; S Kim; C D Smith
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Neurotoxicology     Volume:  19     ISSN:  0161-813X     ISO Abbreviation:  Neurotoxicology     Publication Date:  1998 Jun 
Date Detail:
Created Date:  1998-09-02     Completed Date:  1998-09-02     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7905589     Medline TA:  Neurotoxicology     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  381-91     Citation Subset:  IM    
Affiliation:
Pharmacology Division, U.S. Army Medical Research Institute of Chemical Defense, Aberdeen Proving Grounds, MD 21010-5425, USA.
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MeSH Terms
Descriptor/Qualifier:
Animals
Body Weight / drug effects
Convulsants / toxicity*
Delta Rhythm / drug effects*
Lethal Dose 50
Male
Rats
Rats, Sprague-Dawley
Seizures / chemically induced,  physiopathology*
Soman / toxicity*
Chemical
Reg. No./Substance:
0/Convulsants; 96-64-0/Soman

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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