Document Detail

Neural factors in acute emetic, cardiovascular, and respiratory effects of T-2 toxin in cats.
MedLine Citation:
PMID:  2513668     Owner:  NLM     Status:  MEDLINE    
T-2 toxin, a trichothecene mycotoxin, was injected iv or ip in the single lethal dose of 2 mg/kg. Vomiting was elicited in normal and decerebrate cats with an average onset time of 26.6 min. Chronic ablation of the area postrema significantly delayed the emetic latency to 304 min. Polygraph recording revealed a steady decline in mean arterial blood pressure and pulse pressure to an extreme shock level resulting in death after 5 to 15 hr. Heart rate varied unremarkably throughout the course of circulatory failure, and the cardiac beat persisted after respiratory arrest. No protection against the lethal response was afforded by midbrain decerebration, area postrema ablation, section of the carotid sinus and vagus nerves, and high spinal cord transection supported with artificial ventilation. Effects of T-2 toxin on central and reflex control of breathing were evaluated through changes in VT/FACO2 and f/VT relationships generated by delivery of CO2 enriched gas for inhalation. Central CO2 responsiveness was well maintained under all tested neurological conditions up to the stage of terminal collapse with late decreases in delta VT/delta FACO2 gain and FACO2 setpoint. A toxin-induced progressive increase in resting frequency and an associated decrease in delta f/delta VT gain was found in unanesthetized decerebrate cats, though resting f did not change remarkably in the anesthetized brain-intact cats. In vagotomized brain-intact cats, the delta f/delta VT gain was sustained at zero. These findings indicate that T-2 toxin exercised minimal influence on the brain stem CO2-VT regulator but it caused an acceleration of the central respiratory oscillator after interruption of forebrain connections.
H L Borison; M L Goodheart
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Toxicology and applied pharmacology     Volume:  101     ISSN:  0041-008X     ISO Abbreviation:  Toxicol. Appl. Pharmacol.     Publication Date:  1989 Dec 
Date Detail:
Created Date:  1990-02-08     Completed Date:  1990-02-08     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  0416575     Medline TA:  Toxicol Appl Pharmacol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  399-413     Citation Subset:  IM    
Department of Pharmacology and Toxicology, Dartmouth Medical School, Hanover, New Hampshire 03756.
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MeSH Terms
Binding Sites
Brain Stem / anatomy & histology,  drug effects
Carbon Dioxide / diagnostic use
Cardiovascular Physiological Phenomena
Cardiovascular System / drug effects*
Cerebral Ventricles / anatomy & histology,  drug effects*,  surgery
Decerebrate State / physiopathology
Hemodynamics / drug effects
Respiration / drug effects*,  physiology
Sesquiterpenes / toxicity*
T-2 Toxin / toxicity*
Tidal Volume
Vomiting / chemically induced*
Grant Support
Reg. No./Substance:
0/Sesquiterpenes; 124-38-9/Carbon Dioxide; 21259-20-1/T-2 Toxin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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