Document Detail

Neural crest stem cell population in craniomaxillofacial development and tissue repair.
MedLine Citation:
PMID:  25350250     Owner:  NLM     Status:  In-Data-Review    
Neural crest cells, delaminating from the neural tube during migration, undergo an epithelial-mesenchymal transition and differentiate into several cell types strongly reinforcing the mesoderm of the craniofacial body area - giving rise to bone, cartilage and other tissues and cells of this human body area. Recent studies on craniomaxillofacial neural crest-derived cells have provided evidence for the tremendous plasticity of these cells. Actually, neural crest cells can respond and adapt to the environment in which they migrate and the cranial mesoderm plays an important role toward patterning the identity of the migrating neural crest cells. In our experience, neural crest-derived stem cells, such as dental pulp stem cells, can actively proliferate, repair bone and give rise to other tissues and cytotypes, including blood vessels, smooth muscle, adipocytes and melanocytes, highlighting that their use in tissue engineering is successful. In this review, we provide an overview of the main pathways involved in neural crest formation, delamination, migration and differentiation; and, in particular, we concentrate our attention on the translatability of the latest scientific progress. Here we try to suggest new ideas and strategies that are needed to fully develop the clinical use of these cells. This effort should involve both researchers/clinicians and improvements in good manufacturing practice procedures. It is important to address studies towards clinical application or take into consideration that studies must have an effective therapeutic prospect for humans. New approaches and ideas must be concentrated also toward stem cell recruitment and activation within the human body, overcoming the classical grafting.
M La Noce; L Mele; V Tirino; F Paino; A De Rosa; P Naddeo; P Papagerakis; G Papaccio; V Desiderio
Publication Detail:
Type:  Journal Article     Date:  2014-10-28
Journal Detail:
Title:  European cells & materials     Volume:  28     ISSN:  1473-2262     ISO Abbreviation:  Eur Cell Mater     Publication Date:  2014  
Date Detail:
Created Date:  2014-10-29     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100973416     Medline TA:  Eur Cell Mater     Country:  Scotland    
Other Details:
Languages:  eng     Pagination:  348-57     Citation Subset:  IM    
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