Document Detail

Neural crest and somitic mesoderm as paradigms to investigate cell fate decisions during development.
MedLine Citation:
PMID:  23043365     Owner:  NLM     Status:  Publisher    
The dorsal domains of the neural tube and somites are transient embryonic epithelia; they constitute the source of neural crest progenitors that generate the peripheral nervous system, pigment cells and ectomesenchyme, and of the dermomyotome that develops into myocytes, dermis and vascular cells, respectively. Based on the variety of derivatives produced by each type of epithelium, a classical yet still highly relevant question is whether these embryonic epithelia are composed of homogeneous multipotent progenitors or, alternatively, of subsets of fate-restricted cells. Growing evidence substantiates the notion that both the dorsal tube and the dermomyotome are heterogeneous epithelia composed of multipotent as well as fate-restricted precursors that emerge as such in a spatio-temporally regulated manner. Elucidation of the state of commitment of the precedent progenitors is of utmost significance for deciphering the mechanisms that regulate fate segregation during embryogenesis. In addition, it will contribute to understanding the nature of well documented neural crest-somite interactions shown to modulate the timing of neural crest cell emigration, their segmental migration, and myogenesis.
Erez Nitzan; Chaya Kalcheim
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-10-8
Journal Detail:
Title:  Development, growth & differentiation     Volume:  -     ISSN:  1440-169X     ISO Abbreviation:  Dev. Growth Differ.     Publication Date:  2012 Oct 
Date Detail:
Created Date:  2012-10-9     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0356504     Medline TA:  Dev Growth Differ     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
© 2012 The Authors Development, Growth & Differentiation © 2012 Japanese Society of Developmental Biologists.
Department of Medical Neurobiology, Institute for Medical Research Israel-Canada, and Edmond and Lily Safra Center for Brain Sciences - Hebrew University-Hadassah Medical School, Jerusalem 91120, PO Box 12272, Israel.
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