Document Detail


Neural crest origin of olfactory ensheathing glia.
MedLine Citation:
PMID:  21078992     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Olfactory ensheathing cells (OECs) are a unique class of glial cells with exceptional translational potential because of their ability to support axon regeneration in the central nervous system. Although OECs are similar in many ways to immature and nonmyelinating Schwann cells, and can myelinate large-diameter axons indistinguishably from myelination by Schwann cells, current dogma holds that OECs arise from the olfactory epithelium. Here, using fate-mapping techniques in chicken embryos and genetic lineage tracing in mice, we show that OECs in fact originate from the neural crest and hence share a common developmental heritage with Schwann cells. This explains the similarities between OECs and Schwann cells and overturns the existing dogma on the developmental origin of OECs. Because neural crest stem cells persist in adult tissue, including skin and hair follicles, our results also raise the possibility that patient-derived neural crest stem cells could in the future provide an abundant and accessible source of autologous OECs for cell transplantation therapy for the injured central nervous system.
Authors:
Perrine Barraud; Anastasia A Seferiadis; Luke D Tyson; Maarten F Zwart; Heather L Szabo-Rogers; Christiana Ruhrberg; Karen J Liu; Clare V H Baker
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2010-11-15
Journal Detail:
Title:  Proceedings of the National Academy of Sciences of the United States of America     Volume:  107     ISSN:  1091-6490     ISO Abbreviation:  Proc. Natl. Acad. Sci. U.S.A.     Publication Date:  2010 Dec 
Date Detail:
Created Date:  2010-12-08     Completed Date:  2011-01-31     Revised Date:  2013-07-03    
Medline Journal Info:
Nlm Unique ID:  7505876     Medline TA:  Proc Natl Acad Sci U S A     Country:  United States    
Other Details:
Languages:  eng     Pagination:  21040-5     Citation Subset:  IM    
Affiliation:
Department of Physiology, University of Cambridge, Cambridge CB2 3DY, United Kingdom.
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MeSH Terms
Descriptor/Qualifier:
Animals
Cell Lineage*
Cell Transplantation
Chick Embryo
Cytological Techniques
Humans
Mice
Neural Crest / cytology*
Neuroglia / cytology*
Olfactory Mucosa / cytology*
Regenerative Medicine / methods
Schwann Cells
Grant Support
ID/Acronym/Agency:
078087//Wellcome Trust; 081880//Wellcome Trust; 082556//Wellcome Trust
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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