Document Detail

Neural crest cell migration in the developing embryo.
MedLine Citation:
PMID:  14731657     Owner:  NLM     Status:  PubMed-not-MEDLINE    
In vertebrate embryos, neural crest cells migrate extensively to defined sites where they differentiate into a complex array of derivatives, ranging from neurons to pigment cells. Neural crest cells emerge uniformly from the neural tube but their subsequent migratory pattern is segmented along much of the body axis. What factors control this segmental migration? At trunk levels, it is imposed by the intrinsic segmentation of the neighbouring somitic mesoderm, while in the head, intrinsic information within the neural tube as well as extrinsic influences from the ectoderm are involved. A variety of cell-cell and cell-extracellular matrix interactions are thought to influence initiation and movement of neural crest cells. This review summarizes recent progress from both experimental embryology and cell biology approaches in uncovering the mechanisms underlying neural crest cell migration.
M Bronner-Fraser
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Trends in cell biology     Volume:  3     ISSN:  0962-8924     ISO Abbreviation:  Trends Cell Biol.     Publication Date:  1993 Nov 
Date Detail:
Created Date:  2004-01-20     Completed Date:  2004-02-03     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9200566     Medline TA:  Trends Cell Biol     Country:  England    
Other Details:
Languages:  eng     Pagination:  392-7     Citation Subset:  -    
Developmental Biology Center, University of California, Irvine, CA 92717, USA.
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