Document Detail


Neural correlates to food-related behavior in normal-weight and overweight/obese participants.
MedLine Citation:
PMID:  23028988     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Two thirds of US adults are either obese or overweight and this rate is rising. Although the etiology of obesity is not yet fully understood, neuroimaging studies have demonstrated that the central nervous system has a principal role in regulating eating behavior. In this study, functional magnetic resonance imaging and survey data were evaluated for correlations between food-related problem behaviors and the neural regions underlying responses to visual food cues before and after eating in normal-weight individuals and overweight/obese individuals. In normal-weight individuals, activity in the left amygdala in response to high-calorie food vs. nonfood object cues was positively correlated with impaired satiety scores during fasting, suggesting that those with impaired satiety scores may have an abnormal anticipatory reward response. In overweight/obese individuals, activity in the dorsolateral prefrontal cortex (DLPFC) in response to low-calorie food cues was negatively correlated with impaired satiety during fasting, suggesting that individuals scoring lower in satiety impairment were more likely to activate the DLPFC inhibitory system. After eating, activity in both the putamen and the amygdala was positively correlated with impaired satiety scores among obese/overweight participants. While these individuals may volitionally suggest they are full, their functional response to food cues suggests food continues to be salient. These findings suggest brain regions involved in the evaluation of visual food cues may be mediated by satiety-related problems, dependent on calorie content, state of satiation, and body mass index.
Authors:
Alan Ho; James Kennedy; Anastasia Dimitropoulos
Related Documents :
24879868 - Diet-dependent modulation of gastro-oesphageal vagal afferent mechanosensitivity by end...
24695718 - Binge-like consumption of a palatable food accelerates habitual control of behavior and...
24897248 - Food preference behaviour of the five-striped squirrel, funambulus pennanti wroughton.
78658 - Pseudo-exfoliation fibrils examined by negative staining.
16114008 - Lymphoscintigraphic drainage patterns of the auricle in healthy subjects.
16885928 - Pattern of dietary fiber intake among the japanese general population.
Publication Detail:
Type:  Clinical Trial; Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.     Date:  2012-09-18
Journal Detail:
Title:  PloS one     Volume:  7     ISSN:  1932-6203     ISO Abbreviation:  PLoS ONE     Publication Date:  2012  
Date Detail:
Created Date:  2012-10-02     Completed Date:  2013-02-25     Revised Date:  2013-07-11    
Medline Journal Info:
Nlm Unique ID:  101285081     Medline TA:  PLoS One     Country:  United States    
Other Details:
Languages:  eng     Pagination:  e45403     Citation Subset:  IM    
Affiliation:
Department of Psychological Sciences, Case Western Reserve University, Cleveland, Ohio, United States of America.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Adult
Body Mass Index
Brain / physiology
Feeding Behavior / physiology
Female
Humans
Magnetic Resonance Imaging
Male
Obesity / physiopathology*
Overweight / physiopathology*
Prefrontal Cortex / physiology
Reward
Satiation / physiology
Young Adult
Grant Support
ID/Acronym/Agency:
R03HD058766-01/HD/NICHD NIH HHS; UL1 RR024989/RR/NCRR NIH HHS; UL1 RR024989/RR/NCRR NIH HHS
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Expression of TIP-1 confers radioresistance of malignant glioma cells.
Next Document:  Fingers crossed! An investigation of somatotopic representations using spatial directional judgement...