Document Detail


Neural correlates of prior expectations of motion in the lateral intraparietal and middle temporal areas.
MedLine Citation:
PMID:  22815520     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Successful decision making involves combining observations of the external world with prior knowledge. Recent studies suggest that neural activity in macaque lateral intraparietal area (LIP) provides a useful window into this process. This study examines how rapidly changing prior knowledge about an upcoming sensory stimulus influences the computations that convert sensory signals into plans for action. Two monkeys performed a cued direction discrimination task, in which an arrow cue presented at the start of each trial communicated the prior probability of the direction of stimulus motion. We hypothesized that the cue would either shift the initial level of LIP activity before sensory evidence arrived, or it would scale sensory responses according to the prior probability of each stimulus, manifesting as a change in slope of LIP firing rates. Neural recordings demonstrated a clear shift in the activity level of LIP neurons following the arrow cue, which persisted into the presentation of the motion stimulus. No significant change in slope of responses was observed, suggesting that sensory gain was not strongly modulated. To confirm the latter observation, middle temporal area (MT) neurons were recorded during a version of the cued direction discrimination task, and we found no change in MT responses resulting from the presentation of the directional cue. These results suggest that information about an immediately upcoming stimulus does not scale the sensory response, but rather changes the amount of evidence that must be accumulated to reach a decision in areas that are involved in planning action.
Authors:
Vinod Rao; Gregory C DeAngelis; Lawrence H Snyder
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural    
Journal Detail:
Title:  The Journal of neuroscience : the official journal of the Society for Neuroscience     Volume:  32     ISSN:  1529-2401     ISO Abbreviation:  J. Neurosci.     Publication Date:  2012 Jul 
Date Detail:
Created Date:  2012-07-20     Completed Date:  2012-10-24     Revised Date:  2013-07-12    
Medline Journal Info:
Nlm Unique ID:  8102140     Medline TA:  J Neurosci     Country:  United States    
Other Details:
Languages:  eng     Pagination:  10063-74     Citation Subset:  IM    
Affiliation:
Department of Anatomy and Neurobiology, Washington University School of Medicine, Saint Louis, Missouri 63110, USA.
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MeSH Terms
Descriptor/Qualifier:
Action Potentials / physiology*
Animals
Attention / physiology*
Cues
Discrimination (Psychology) / physiology
Macaca mulatta
Male
Motion
Motion Perception / physiology*
Neurons / physiology*
Parietal Lobe / physiology*
Photic Stimulation
Reaction Time / physiology
Temporal Lobe / physiology*
Grant Support
ID/Acronym/Agency:
EY002687/EY/NEI NIH HHS; EY012135/EY/NEI NIH HHS; EY013644/EY/NEI NIH HHS; F30 MH077368-01A1/MH/NIMH NIH HHS; P30 EY002687/EY/NEI NIH HHS; R01 EY012135/EY/NEI NIH HHS; R01 EY013644/EY/NEI NIH HHS
Comments/Corrections

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