Document Detail

Neural correlates of craving and resisting craving for tobacco in nicotine dependent smokers.
MedLine Citation:
PMID:  21790899     Owner:  NLM     Status:  MEDLINE    
Craving is a significant factor which can lead to relapse during smoking quit attempts. Attempts to resist urges to smoke during cue-elicited craving have been shown to activate regions in the brain associated with decision-making, anxiety regulation and visual processing. In this study, 32 treatment-seeking, nicotine-dependent smokers viewed blocks of smoking and neutral cues alternating with rest periods during magnetic resonance imaging scanning in a 3T Siemens scanner (Siemens AG, Erlangen, Bavaria, Germany). While viewing cues or control images, participants were instructed either to 'allow yourself to crave' or 'resist craving.' Data were analyzed with FSL 4.1.5, focused on the smoking cues versus neutral cues contrast, using cluster thresholding (Z > 2.3 and corrected cluster threshold of P = 0.05) at the individual and group levels. During the Crave condition, activation was seen on the left anterior cingulated cortex (LACC), medial prefrontal cortex, left middle cingulate gyrus, bilateral posterior cingulated gyrus and bilateral precuneus, areas associated with attention, decision-making and episodic memory. The LACC and areas of the prefrontal cortex associated with higher executive functioning were activated during the Resist condition. No clear distinctions between group crave and resist analyses as a whole were seen without taking into account specific strategies used to resist the urge to smoke, supporting the idea that craving is associated with some degree of resisting the urge to smoke, and trying to resist is almost always accompanied by some degree of craving. Different strategies for resisting, such as distraction, activated different regions. Understanding the underlying neurobiology of resisting craving to smoke may identify new foci for treatments.
Karen J Hartwell; Kevin A Johnson; Xingbao Li; Hugh Myrick; Todd LeMatty; Mark S George; Kathleen T Brady
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't     Date:  2011-07-25
Journal Detail:
Title:  Addiction biology     Volume:  16     ISSN:  1369-1600     ISO Abbreviation:  Addict Biol     Publication Date:  2011 Oct 
Date Detail:
Created Date:  2011-09-20     Completed Date:  2012-03-06     Revised Date:  2014-09-24    
Medline Journal Info:
Nlm Unique ID:  9604935     Medline TA:  Addict Biol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  654-66     Citation Subset:  IM    
Copyright Information:
© 2011 The Authors, Addiction Biology © 2011 Society for the Study of Addiction.
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MeSH Terms
Arousal / physiology
Brain / physiopathology*
Brain Mapping
Dominance, Cerebral / physiology
Image Processing, Computer-Assisted*
Magnetic Resonance Imaging*
Middle Aged
Motivation / physiology*
Smoking Cessation / psychology*
Substance Withdrawal Syndrome / physiopathology*
Tobacco Use Disorder / physiopathology*,  rehabilitation
Young Adult
Grant Support
5R21DA026085-02/DA/NIDA NIH HHS; K12HD055885/HD/NICHD NIH HHS; R21 DA026085/DA/NIDA NIH HHS; R21 DA026085-01/DA/NIDA NIH HHS; R21 DA026085-02/DA/NIDA NIH HHS; R33 DA026085/DA/NIDA NIH HHS; R33 DA026085-03/DA/NIDA NIH HHS; R33 DA026085-04/DA/NIDA NIH HHS; UL1 RR029882/RR/NCRR NIH HHS; UL1 RR029882/RR/NCRR NIH HHS; UL1 RR029882-01/RR/NCRR NIH HHS

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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