| Neural correlates of STN DBS-induced cognitive variability in Parkinson disease. | |
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MedLine Citation:
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PMID: 18682259 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Although deep brain stimulation of the subthalamic nucleus (STN DBS) in Parkinson disease (PD) improves motor function, it has variable effects on working memory (WM) and response inhibition (RI) performance. The purpose of this study was to determine the neural correlates of STN DBS-induced variability in cognitive performance. METHODS: We measured bilateral STN DBS-induced blood flow changes (PET and [(15)O]-water on one day) in the supplementary motor area (SMA), dorsolateral prefrontal cortex (DLPFC), anterior cingulate cortex (ACC), and right inferior frontal cortex (rIFC) as well as in exploratory ROIs defined by published meta-analyses. STN DBS-induced WM and RI changes (Spatial Delayed Response and Go-No-Go on the next day) were measured in 24 PD participants. On both days, participants withheld PD medications overnight and conditions (OFF vs. ON) were administered in a counterbalanced, double-blind manner. RESULTS: As predicted, STN DBS-induced DLPFC blood flow change correlated with change in WM, but not RI performance. Furthermore, ACC blood flow change correlated with change in RI but not WM performance. For both relationships, increased blood flow related to decreased cognitive performance in response to STN DBS. Of the exploratory regions, only blood flow changes in DLPFC and ACC were correlated with performance. CONCLUSIONS: These results demonstrate that variability in the effects of STN DBS on cognitive performance relates to STN DBS-induced cortical blood flow changes in DLPFC and ACC. This relationship highlights the need to further understand the factors that mediate the variability in neural and cognitive response to STN DBS. |
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Authors:
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M C Campbell; M Karimi; P M Weaver; J Wu; D C Perantie; N A Golchin; S D Tabbal; J S Perlmutter; T Hershey |
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Publication Detail:
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Type: Clinical Trial; Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't Date: 2008-07-19 |
Journal Detail:
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Title: Neuropsychologia Volume: 46 ISSN: 0028-3932 ISO Abbreviation: Neuropsychologia Publication Date: 2008 Nov |
Date Detail:
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Created Date: 2008-09-08 Completed Date: 2009-02-03 Revised Date: 2012-05-28 |
Medline Journal Info:
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Nlm Unique ID: 0020713 Medline TA: Neuropsychologia Country: England |
Other Details:
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Languages: eng Pagination: 3162-9 Citation Subset: IM |
Affiliation:
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Department of Psychiatry, Washington University School of Medicine, St. Louis, MO 63110, United States. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Aged Analysis of Variance Brain Mapping* Cognition Disorders / etiology* Deep Brain Stimulation / adverse effects* Female Gyrus Cinguli / blood supply, radionuclide imaging Humans Male Memory, Short-Term / physiology, radiation effects Middle Aged Neuropsychological Tests Parkinson Disease / radionuclide imaging, therapy* Positron-Emission Tomography Prefrontal Cortex / blood supply, radionuclide imaging Subthalamic Nucleus / physiology, radiation effects*, radionuclide imaging |
| Grant Support | |
ID/Acronym/Agency:
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DA07261/DA/NIDA NIH HHS; K23 NS041248-05/NS/NINDS NIH HHS; NS057105/NS/NINDS NIH HHS; NS41248/NS/NINDS NIH HHS; NS41509/NS/NINDS NIH HHS; P30 NS057105-01/NS/NINDS NIH HHS; R01 NS041509/NS/NINDS NIH HHS; R01 NS041509-07/NS/NINDS NIH HHS; R01 NS050425-05/NS/NINDS NIH HHS; R01 NS058714-03/NS/NINDS NIH HHS; T32 DA007261-17/DA/NIDA NIH HHS |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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