Document Detail

Neural control of renal function in edema-forming states.
MedLine Citation:
PMID:  3381907     Owner:  NLM     Status:  MEDLINE    
To define the role of the renal nerves in renal sodium-retaining edema-forming states, experiments were conducted in conscious chronically instrumented rats with congestive heart failure (myocardial infarction), nephrotic syndrome (adriamycin injection), and hepatic cirrhosis (common bile duct ligation). In each experimental model, renal excretion, as water or sodium, of an acutely administered oral or intravenous isotonic saline load was significantly less than that in control rats. Bilateral renal denervation of the experimental rats restored their renal excretory response to that of the control rats. In addition, in response to the acute administration of a standard intravenous isotonic saline load, the decrease in efferent renal sympathetic nerve activity was significantly less in all three experimental models compared with that of control rats. These results suggest that the impaired ability to excrete an acute isotonic saline load in these experimental models is partially dependent on an increase in basal efferent renal sympathetic nerve activity that fails to suppress normally in response to the isotonic saline load.
G F DiBona; P J Herman; L L Sawin
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  The American journal of physiology     Volume:  254     ISSN:  0002-9513     ISO Abbreviation:  Am. J. Physiol.     Publication Date:  1988 Jun 
Date Detail:
Created Date:  1988-07-15     Completed Date:  1988-07-15     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0370511     Medline TA:  Am J Physiol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  R1017-24     Citation Subset:  IM    
Department of Internal Medicine, University of Iowa College of Medicine, Iowa City.
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MeSH Terms
Disease Models, Animal
Doxorubicin / pharmacology
Edema / physiopathology*
Efferent Pathways / drug effects,  physiopathology
Heart Failure / physiopathology*
Kidney / innervation*,  physiology,  physiopathology
Liver Cirrhosis / physiopathology*
Nephrotic Syndrome / physiopathology*
Rats, Inbred Strains
Reference Values
Sympathetic Nervous System / drug effects,  physiology,  physiopathology*
Grant Support
Reg. No./Substance:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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