Document Detail


Neural circuitry engaged by prostaglandins during the sickness syndrome.
MedLine Citation:
PMID:  22837039     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
During illnesses caused by infectious disease or other sources of inflammation, a suite of brain-mediated responses called the sickness syndrome occurs, which includes fever, anorexia, sleepiness, hyperalgesia and elevated corticosteroid secretion. Much of the sickness syndrome is mediated by prostaglandins acting on the brain and can be prevented by nonsteroidal anti-inflammatory drugs, such as aspirin or ibuprofen, that block prostaglandin synthesis. By examining which prostaglandins are produced at which sites and how they interact with the nervous system, researchers have identified specific neural circuits that underlie the sickness syndrome.
Authors:
Clifford B Saper; Andrej A Romanovsky; Thomas E Scammell
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Review     Date:  2012-07-26
Journal Detail:
Title:  Nature neuroscience     Volume:  15     ISSN:  1546-1726     ISO Abbreviation:  Nat. Neurosci.     Publication Date:  2012 Aug 
Date Detail:
Created Date:  2012-07-27     Completed Date:  2012-10-25     Revised Date:  2013-08-27    
Medline Journal Info:
Nlm Unique ID:  9809671     Medline TA:  Nat Neurosci     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1088-95     Citation Subset:  IM    
Affiliation:
Department of Neurology, Harvard Medical School, Beth Israel Deaconess Medical Center, Boston, Massachusetts, USA. csaper@bidmc.harvard.edu
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MeSH Terms
Descriptor/Qualifier:
Anti-Inflammatory Agents, Non-Steroidal / pharmacology*,  therapeutic use
Fever / drug therapy,  etiology,  pathology
Humans
Inflammation / complications,  drug therapy*,  physiopathology*
Prostaglandins / metabolism*
Syndrome
Grant Support
ID/Acronym/Agency:
HL095491/HL/NHLBI NIH HHS; NS055367/NS/NINDS NIH HHS; NS072337/NS/NINDS NIH HHS; NS41233/NS/NINDS NIH HHS; P01 HL095491/HL/NHLBI NIH HHS; R01 NS072337/NS/NINDS NIH HHS
Chemical
Reg. No./Substance:
0/Anti-Inflammatory Agents, Non-Steroidal; 0/Prostaglandins
Comments/Corrections

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