Document Detail


Neural cell adhesion molecules (NCAM) and NCAM-PSA expression in neuroendocrine lung tumors.
MedLine Citation:
PMID:  9777989     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Neural cell adhesion molecules (NCAM) represent specific markers of neuroendocrine (NE) differentiation in lung cancer. Because the polysialic acid form (NCAM-PSA) has reduced adhesion properties, we hypothesized that NCAM-PSA expression could favor metastatic spread. Immunostaining of NCAM and NCAM-PSA were therefore compared in 120 NE lung tumors, including 17 typical carcinoids, 3 atypical carcinoids, 30 large cell NE carcinomas and 70 small cell lung carcinomas, as compared with 25 adenocarcinomas and 25 squamous cell carcinomas. Neural cell adhesion molecules were negative in adenocarcinomas and squamous cell carcinomas but were constantly expressed in all NE tumors from typical carcinoids to small cell lung carcinomas. NCAM-PSA expression was significantly more frequent in high-grade tumors, with 24 of 30 positive cases in large cell NE carcinomas and 65 of 70 positive cases in small cell lung carcinoma, than in carcinoids with 10 of 17 and 2 of 3 positive cases in typical carcinoids and atypical carcinoids, respectively. The neural cell adhesion molecule-polysialic acid form scores of staining were significantly higher in high-grade as compared with low-grade tumors (p = 0.002), and were correlated with nodal spread (p = 0.04) and metastasis (p = 0.016) across histologic classes but not in individual tumor type. We conclude that NCAM-PSA connotes poor differentiation and aggressive clinical behavior in the spectrum of NE lung tumors, but cannot be regarded as a prognostic factor in individual tumor classes.
Authors:
S Lantuejoul; D Moro; R J Michalides; C Brambilla; E Brambilla
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  The American journal of surgical pathology     Volume:  22     ISSN:  0147-5185     ISO Abbreviation:  Am. J. Surg. Pathol.     Publication Date:  1998 Oct 
Date Detail:
Created Date:  1998-10-28     Completed Date:  1998-10-28     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7707904     Medline TA:  Am J Surg Pathol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1267-76     Citation Subset:  IM    
Affiliation:
Laboratoire de Pathologie Cellulaire, Grenoble, France.
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MeSH Terms
Descriptor/Qualifier:
Adenocarcinoma / metabolism,  pathology
Antibodies, Monoclonal / analysis
Carcinoid Tumor / metabolism,  pathology
Carcinoma, Small Cell / metabolism,  pathology
Carcinoma, Squamous Cell / metabolism,  pathology
Cell Count
Chromogranin A
Chromogranins / metabolism
Diagnosis, Differential
Humans
Lung Neoplasms / metabolism*,  mortality,  pathology
Lymphatic Metastasis
Neural Cell Adhesion Molecules / metabolism*
Neuroendocrine Tumors / metabolism*,  mortality,  secondary
Retrospective Studies
Sialic Acids / metabolism*
Survival Rate
Chemical
Reg. No./Substance:
0/Antibodies, Monoclonal; 0/Chromogranin A; 0/Chromogranins; 0/Neural Cell Adhesion Molecules; 0/Sialic Acids
Comments/Corrections
Comment In:
Am J Surg Pathol. 2000 Feb;24(2):319-20   [PMID:  10680908 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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