Document Detail


Neural basis for the genesis and control of digitalis arrhythmias.
MedLine Citation:
PMID:  975124     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The pharmacokinetics of ouabain associated with toxicity were studied in the cat and the guinea pig both in vivo and in vitro using ouabain-H3. After spinal cord transection a higher dose of ouabain was required to reach the lethal endpoint. This intervention also increased the myocardial and serum levels associated with toxicity were studied in the cat and the guinea pig both in vivo and in vitro using ouabain-H3. After spinal cord transection a higher dose of ouabain was required to reach the lethal endpoint. This intervention also increased the myocardial and serum levels associated with death. These findings were corroborated in experiments using digitoxin H3. In vitro, substantially higher ouabain tissue contents were associated with a lethal event. In addition, in cats and guinea pigs, the lethal myocardial ouabain content did not change when the infusion rate of ouabain was varied in vivo or the perfusate ouabain concentration was changed in vitro. In vivo, propranolol increases the myocardial ouabain content associated with death to in vitro levels. In vitro, the drugs prolongs the time to death by retarding the myocardial uptake of ouabain. These data suggest that the toxic effects of ouabain in the whole animal are largely neural and in the isolated heart, substantially myocardial.
Authors:
B Levitt; N A Cagin; J C Somberg; J J Kleid
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Cardiology     Volume:  61     ISSN:  0008-6312     ISO Abbreviation:  Cardiology     Publication Date:  1976  
Date Detail:
Created Date:  1977-01-03     Completed Date:  1977-01-03     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  1266406     Medline TA:  Cardiology     Country:  SWITZERLAND    
Other Details:
Languages:  eng     Pagination:  50-60     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Animals
Arrhythmias, Cardiac / chemically induced*
Blood Pressure
Cats
Guinea Pigs
Heart Rate / drug effects
Myocardium / metabolism
Ouabain / blood,  metabolism,  toxicity*
Propranolol / pharmacology
Chemical
Reg. No./Substance:
525-66-6/Propranolol; 630-60-4/Ouabain

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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