Document Detail


Neural anomaly and reorganization in speakers who stutter: a short-term intervention study.
MedLine Citation:
PMID:  22875083     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVES: The aim of the current study was to differentiate between neural activity that represents neural anomalies that are responsible for persistent developmental stuttering (PDS) from the activity that is a result of compensating for stuttering. This was done by investigating alterations to the intrinsic functional architecture of speech-language processes of patients with PDS before and after a short-term intervention.
METHODS: The resting-state functional connectivity (RSFC) and cortical thickness were examined before and after the intervention. The structural data were used to validate the functional results. Fifteen stuttering patients who received intervention (PDS+), 13 stuttering patients who did not receive intervention (PDS-), and 13 fluent controls participated.
RESULTS: Before the intervention, both groups of PDS patients showed significant RSFC and cortical thickness reductions in the left pars-opercularis (PO) and RSFC increases in the cerebellum, as compared to fluent controls. The intervention was effective in reducing stuttering in PDS+ patients and lowering their RSFC in the cerebellum to the level of fluent controls. The intervention effect was specific to the PDS+ group (it was not evident in the PDS- group). The intervention did not change RSFC and cortical thickness in the left PO, which remained at its preintervention level.
CONCLUSIONS: The results suggest that the left PO is a locus where the intrinsic functional architecture of speech-language processes is altered in PDS patients, suggesting an etiologic role of this region in PDS. The cerebellum showed intervention-induced neural reorganization, suggesting a compensatory response when stuttering occurs.
Authors:
Chunming Lu; Chuansheng Chen; Danling Peng; Wenping You; Xuhui Zhang; Guosheng Ding; Xiaoxiang Deng; Qian Yan; Peter Howell
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2012-08-08
Journal Detail:
Title:  Neurology     Volume:  79     ISSN:  1526-632X     ISO Abbreviation:  Neurology     Publication Date:  2012 Aug 
Date Detail:
Created Date:  2012-08-14     Completed Date:  2012-10-24     Revised Date:  2013-05-29    
Medline Journal Info:
Nlm Unique ID:  0401060     Medline TA:  Neurology     Country:  United States    
Other Details:
Languages:  eng     Pagination:  625-32     Citation Subset:  AIM; IM    
Affiliation:
State Key Laboratory of Cognitive Neuroscience and Learning, Beijing Normal University, Beijing, PR China. luchunming@bnu.edu.cn
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MeSH Terms
Descriptor/Qualifier:
Adult
Behavior Therapy*
Brain / physiopathology*
Brain Mapping
Female
Functional Laterality / physiology
Humans
Image Processing, Computer-Assisted
Male
Nerve Net / physiopathology*
Speech Perception / physiology
Stuttering / physiopathology*,  therapy*
Treatment Outcome
Comments/Corrections
Comment In:
Neurology. 2012 Aug 14;79(7):614-5   [PMID:  22875088 ]
Neurology. 2013 Apr 16;80(16):1538   [PMID:  23589641 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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