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Neural agryrophilia induced by puromycin: A directed Golgi-like method.
MedLine Citation:
PMID:  19604849     Owner:  NLM     Status:  In-Data-Review    
Puromycin injected intracerebrally in rats renders affected neurons extremely argyrophilic, which makes it possible to demonstrate their fine geometry by the aid of a reduced silver impregnation procedure. The technique shows promise as a directed Golgi-like method. The abortive action of puromycin on protein synthesis produces a multitude of argyrophilic peptide fragments, which are subsequently transported throughout the neuron as protein-like moieties. It is hypothesized that these fragments serve as nucleation points for subsequent silver deposition.
R C Switzer
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Neuroscience letters     Volume:  2     ISSN:  0304-3940     ISO Abbreviation:  Neurosci. Lett.     Publication Date:  1976 Aug 
Date Detail:
Created Date:  2009-07-16     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7600130     Medline TA:  Neurosci Lett     Country:  Ireland    
Other Details:
Languages:  eng     Pagination:  301-5     Citation Subset:  -    
Department of Anatomy, University of Virginia, Charlottesville, Va. 22901 U.S.A.
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