| Neural agryrophilia induced by puromycin: A directed Golgi-like method. | |
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MedLine Citation:
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PMID: 19604849 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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Puromycin injected intracerebrally in rats renders affected neurons extremely argyrophilic, which makes it possible to demonstrate their fine geometry by the aid of a reduced silver impregnation procedure. The technique shows promise as a directed Golgi-like method. The abortive action of puromycin on protein synthesis produces a multitude of argyrophilic peptide fragments, which are subsequently transported throughout the neuron as protein-like moieties. It is hypothesized that these fragments serve as nucleation points for subsequent silver deposition. |
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Authors:
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R C Switzer |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Neuroscience letters Volume: 2 ISSN: 0304-3940 ISO Abbreviation: Neurosci. Lett. Publication Date: 1976 Aug |
Date Detail:
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Created Date: 2009-07-16 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7600130 Medline TA: Neurosci Lett Country: Ireland |
Other Details:
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Languages: eng Pagination: 301-5 Citation Subset: - |
Affiliation:
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Department of Anatomy, University of Virginia, Charlottesville, Va. 22901 U.S.A. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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