Document Detail


Neural responses to visual food stimuli after a normal vs. higher protein breakfast in breakfast-skipping teens: a pilot fMRI study.
MedLine Citation:
PMID:  21546927     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
This functional magnetic resonance imaging (fMRI) pilot study identified whether breakfast consumption would alter the neural activity in brain regions associated with food motivation and reward in overweight "breakfast skipping" (BS) adolescent girls and examined whether increased protein at breakfast would lead to additional alterations. Ten girls (Age: 15 ± 1 years; BMI percentile 93 ± 1%; BS 5 ± 1×/week) completed 3 testing days. Following the BS day, the participants were provided with, in randomized order, normal protein (NP; 18 ± 1 g protein) or higher protein (HP; 50 ± 1 g protein) breakfast meals to consume at home for 6 days. On day 7 of each pattern, the participants came to the laboratory to consume their respective breakfast followed by appetite questionnaires and an fMRI brain scan to identify brain activation responses to viewing food vs. nonfood images prior to lunch. Breakfast consumption led to enduring (i.e., 3-h post breakfast) reductions in neural activation in the hippocampus, amygdala, cingulate, and parahippocampus vs. BS. HP led to enduring reductions in insula and middle prefrontal cortex activation vs. NP. Hippocampal, amygdala, cingulate, and insular activations were correlated with appetite and inversely correlated with satiety. In summary, the addition of breakfast led to alterations in brain activation in regions previously associated with food motivation and reward with additional alterations following the higher-protein breakfast. These data suggest that increased dietary protein at breakfast might be a beneficial strategy to reduce reward-driven eating behavior in overweight teen girls. Due to the small sample size, caution is warranted when interpreting these preliminary findings.
Authors:
Heather J Leidy; Rebecca J Lepping; Cary R Savage; Corey T Harris
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Publication Detail:
Type:  Journal Article; Randomized Controlled Trial; Research Support, N.I.H., Extramural     Date:  2011-05-05
Journal Detail:
Title:  Obesity (Silver Spring, Md.)     Volume:  19     ISSN:  1930-739X     ISO Abbreviation:  Obesity (Silver Spring)     Publication Date:  2011 Oct 
Date Detail:
Created Date:  2011-09-28     Completed Date:  2012-03-27     Revised Date:  2014-05-29    
Medline Journal Info:
Nlm Unique ID:  101264860     Medline TA:  Obesity (Silver Spring)     Country:  United States    
Other Details:
Languages:  eng     Pagination:  2019-25     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Appetite / physiology*
Body Mass Index
Brain / physiology*
Brain Mapping
Diet
Dietary Proteins / administration & dosage*
Feeding Behavior / physiology*
Female
Food*
Humans
Magnetic Resonance Imaging
Motivation / physiology
Overweight / physiopathology,  psychology*
Photic Stimulation / methods
Pilot Projects
Questionnaires
Reward
Satiety Response / physiology*
Grant Support
ID/Acronym/Agency:
K12 HD052027/HD/NICHD NIH HHS; K12 HD052027-04/HD/NICHD NIH HHS
Chemical
Reg. No./Substance:
0/Dietary Proteins
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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