Document Detail


Neural mechanisms associated with food motivation in obese and healthy weight adults.
MedLine Citation:
PMID:  19629052     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
One out of three adults in the United States is clinically obese. Excess food intake is associated with food motivation, which has been found to be higher in obese compared to healthy weight (HW) individuals. Little is known, however, regarding the neural mechanisms associated with food motivation in obese compared to HW adults. The current study used functional magnetic resonance imaging (fMRI) to examine changes in the hemodynamic response in obese and HW adults while they viewed food and nonfood images in premeal and postmeal states. During the premeal condition, obese participants showed increased activation, compared to HW participants, in anterior cingulate cortex (ACC) and medial prefrontal cortex (MPFC). Moreover, in the obese group, self-report measures of disinhibition were negatively correlated with premeal ACC activations and self-report measures of hunger were positively correlated with premeal MPFC activations. During the postmeal condition, obese participants also showed greater activation than HW participants in the MPFC. These results indicate that brain function associated with food motivation differs in obese and HW adults and may have implications for understanding brain mechanisms contributing to overeating and obesity, and variability in response to diet interventions.
Authors:
Laura E Martin; Laura M Holsen; Rebecca J Chambers; Amanda S Bruce; William M Brooks; Jennifer R Zarcone; Merlin G Butler; Cary R Savage
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't     Date:  2009-07-23
Journal Detail:
Title:  Obesity (Silver Spring, Md.)     Volume:  18     ISSN:  1930-739X     ISO Abbreviation:  Obesity (Silver Spring)     Publication Date:  2010 Feb 
Date Detail:
Created Date:  2010-01-29     Completed Date:  2010-02-22     Revised Date:  2012-08-13    
Medline Journal Info:
Nlm Unique ID:  101264860     Medline TA:  Obesity (Silver Spring)     Country:  United States    
Other Details:
Languages:  eng     Pagination:  254-60     Citation Subset:  IM    
Affiliation:
Hoglund Brain Imaging Center, University of Kansas Medical Center, Kansas City, Kansas, USA.
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MeSH Terms
Descriptor/Qualifier:
Brain Mapping / methods
Case-Control Studies
Cerebrovascular Circulation*
Fasting
Feeding Behavior*
Female
Humans
Hunger
Limbic System / blood supply,  physiopathology*
Magnetic Resonance Imaging
Male
Motivation*
Obesity / physiopathology*,  psychology*
Photic Stimulation
Postprandial Period
Prefrontal Cortex / blood supply,  physiopathology*
Grant Support
ID/Acronym/Agency:
AG026482/AG/NIA NIH HHS; HD02528/HD/NICHD NIH HHS; NS039123/NS/NINDS NIH HHS

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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