| Neural mechanisms associated with food motivation in obese and healthy weight adults. | |
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MedLine Citation:
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PMID: 19629052 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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One out of three adults in the United States is clinically obese. Excess food intake is associated with food motivation, which has been found to be higher in obese compared to healthy weight (HW) individuals. Little is known, however, regarding the neural mechanisms associated with food motivation in obese compared to HW adults. The current study used functional magnetic resonance imaging (fMRI) to examine changes in the hemodynamic response in obese and HW adults while they viewed food and nonfood images in premeal and postmeal states. During the premeal condition, obese participants showed increased activation, compared to HW participants, in anterior cingulate cortex (ACC) and medial prefrontal cortex (MPFC). Moreover, in the obese group, self-report measures of disinhibition were negatively correlated with premeal ACC activations and self-report measures of hunger were positively correlated with premeal MPFC activations. During the postmeal condition, obese participants also showed greater activation than HW participants in the MPFC. These results indicate that brain function associated with food motivation differs in obese and HW adults and may have implications for understanding brain mechanisms contributing to overeating and obesity, and variability in response to diet interventions. |
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Authors:
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Laura E Martin; Laura M Holsen; Rebecca J Chambers; Amanda S Bruce; William M Brooks; Jennifer R Zarcone; Merlin G Butler; Cary R Savage |
Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't Date: 2009-07-23 |
Journal Detail:
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Title: Obesity (Silver Spring, Md.) Volume: 18 ISSN: 1930-739X ISO Abbreviation: Obesity (Silver Spring) Publication Date: 2010 Feb |
Date Detail:
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Created Date: 2010-01-29 Completed Date: 2010-02-22 Revised Date: 2012-08-13 |
Medline Journal Info:
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Nlm Unique ID: 101264860 Medline TA: Obesity (Silver Spring) Country: United States |
Other Details:
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Languages: eng Pagination: 254-60 Citation Subset: IM |
Affiliation:
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Hoglund Brain Imaging Center, University of Kansas Medical Center, Kansas City, Kansas, USA. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Brain Mapping
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methods Case-Control Studies Cerebrovascular Circulation* Fasting Feeding Behavior* Female Humans Hunger Limbic System / blood supply, physiopathology* Magnetic Resonance Imaging Male Motivation* Obesity / physiopathology*, psychology* Photic Stimulation Postprandial Period Prefrontal Cortex / blood supply, physiopathology* |
| Grant Support | |
ID/Acronym/Agency:
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AG026482/AG/NIA NIH HHS; HD02528/HD/NICHD NIH HHS; NS039123/NS/NINDS NIH HHS |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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