| Neural Mechanisms of Age-Related Slowing: The {Delta}CBF/{Delta}CMRO2 Ratio Mediates Age-Differences in BOLD Signal and Human Performance. | |
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MedLine Citation:
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PMID: 22879349 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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The precise mechanisms that give rise to the blood-oxygen-level-dependent (BOLD) activation differences that accompany age-related cognitive slowing remain fundamentally unknown. We sought to isolate the origin of age-related BOLD changes by comparing blood-flow and oxygen-metabolic constituents of the BOLD response using dual-echo arterial spin labeling during visual stimulation and CO(2) ingestion. We hypothesized, and our results confirmed, that age-related changes in the ratio of fractional cerebral blood flow to fractional cerebral metabolic rate of oxygen consumption (ΔCBF/ΔCMRO(2)) lead to the BOLD changes that are observed in older adults. ΔCBF/ΔCMRO(2) was also significantly related to performance, suggesting that age-related cognitive slowing results from neural cell assemblies that operate less efficiently, requiring greater oxygen metabolism that is not matched by blood-flow changes relative to younger adults. Age-related changes in ΔCBF/ΔCMRO(2) are sufficient to explain variations in BOLD responding and performance cited throughout the literature, assuming no bias based on physiological baseline CMRO(2). |
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Authors:
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Joanna L Hutchison; Hanzhang Lu; Bart Rypma |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2012-8-8 |
Journal Detail:
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Title: Cerebral cortex (New York, N.Y. : 1991) Volume: - ISSN: 1460-2199 ISO Abbreviation: Cereb. Cortex Publication Date: 2012 Aug |
Date Detail:
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Created Date: 2012-8-10 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9110718 Medline TA: Cereb Cortex Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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School of Behavioral and Brain Sciences, University of Texas at Dallas, Richardson, TX 75080, USA. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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