| Neural masking by sub-threshold electric stimuli: animal and computer model results. | |
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MedLine Citation:
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PMID: 21080206 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Electric stimuli can prosthetically excite auditory nerve fibers to partially restore sensory function to individuals impaired by profound or severe hearing loss. While basic response properties of electrically stimulated auditory nerve fibers (ANF) are known, responses to complex, time-changing stimuli used clinically are inadequately understood. We report that forward-masker pulse trains can enhance and reduce ANF responsiveness to subsequent stimuli and the novel observation that sub-threshold (nonspike-evoking) electric trains can reduce responsiveness to subsequent pulse-train stimuli. The effect is observed in the responses of cat ANFs and shown by a computational biophysical ANF model that simulates rate adaptation through integration of external potassium cation (K) channels. Both low-threshold (i.e., Klt) and high-threshold (Kht) channels were simulated at each node of Ranvier. Model versions without Klt channels did not produce the sub-threshold effect. These results suggest that some such accumulation mechanism, along with Klt channels, may underlie sub-threshold masking observed in cat ANF responses. As multichannel auditory prostheses typically present sub-threshold stimuli to various ANF subsets, there is clear relevance of these findings to clinical situations. |
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Authors:
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Charles A Miller; Jihwan Woo; Paul J Abbas; Ning Hu; Barbara K Robinson |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural Date: 2010-11-16 |
Journal Detail:
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Title: Journal of the Association for Research in Otolaryngology : JARO Volume: 12 ISSN: 1438-7573 ISO Abbreviation: J. Assoc. Res. Otolaryngol. Publication Date: 2011 Apr |
Date Detail:
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Created Date: 2011-03-01 Completed Date: 2011-06-16 Revised Date: 2012-04-02 |
Medline Journal Info:
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Nlm Unique ID: 100892857 Medline TA: J Assoc Res Otolaryngol Country: United States |
Other Details:
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Languages: eng Pagination: 219-32 Citation Subset: IM |
Affiliation:
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Department of Otolaryngology, University of Iowa Hospitals & Clinics, 200 Hawkins Drive, Iowa City, IA 52242, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Auditory Threshold / physiology* Cats Cochlear Nerve / physiology* Computer Simulation* Electric Stimulation Models, Animal* Models, Neurological Potassium Channels / physiology Ranvier's Nodes / physiology |
| Grant Support | |
ID/Acronym/Agency:
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R01-DC006478/DC/NIDCD NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Potassium Channels |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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