| Neural crest and ectodermal cells intermix in the nasal placode to give rise to GnRH-1 neurons, sensory neurons, and olfactory ensheathing cells. | |
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MedLine Citation:
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PMID: 21543621 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The origin of GnRH-1 cells and olfactory ensheathing cells has been controversial. Genetic Cre-lox lineage tracing of the neural crest (NC) versus ectodermal contribution to the developing nasal placode was performed using two complementary mouse models, the NC-specific Wnt1Cre mouse line and an ectodermal-specific Crect mouse line. Using these lines we prove that the NC give rise to the olfactory ensheathing cells and subpopulations of GnRH-1 neurons, olfactory and vomeronasal cells. These data demonstrate that Schwann cells and olfactory ensheathing cells share a common developmental origin. Furthermore, the results indicate that certain conditions that impact olfaction and sexual development, such as Kallmann syndrome, may be in part neurocristopathies. |
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Authors:
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Paolo Emanuele Forni; Carol Taylor-Burds; Vida Senkus Melvin; Trevor Williams; Taylor Williams; Susan Wray |
Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: The Journal of neuroscience : the official journal of the Society for Neuroscience Volume: 31 ISSN: 1529-2401 ISO Abbreviation: J. Neurosci. Publication Date: 2011 May |
Date Detail:
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Created Date: 2011-05-05 Completed Date: 2011-08-05 Revised Date: 2011-11-04 |
Medline Journal Info:
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Nlm Unique ID: 8102140 Medline TA: J Neurosci Country: United States |
Other Details:
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Languages: eng Pagination: 6915-27 Citation Subset: IM |
Affiliation:
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Cellular and Developmental Neurobiology Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland 20892, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Cell Count Cell Lineage / physiology* Ectoderm / cytology*, metabolism Gonadotropin-Releasing Hormone / metabolism* Immunohistochemistry Mice Mice, Transgenic Neural Crest / cytology*, metabolism Neurons / cytology*, physiology Schwann Cells / cytology*, metabolism |
| Grant Support | |
ID/Acronym/Agency:
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DE12728/DE/NIDCR NIH HHS |
| Chemical | |
Reg. No./Substance:
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33515-09-2/Gonadotropin-Releasing Hormone |
| Comments/Corrections | |
Erratum In:
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J Neurosci. 2011 Sep 7;31(36):13023 Note: Williams, Taylor [corrected to Williams, Trevor] |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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