Document Detail


Neural crest and ectodermal cells intermix in the nasal placode to give rise to GnRH-1 neurons, sensory neurons, and olfactory ensheathing cells.
MedLine Citation:
PMID:  21543621     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The origin of GnRH-1 cells and olfactory ensheathing cells has been controversial. Genetic Cre-lox lineage tracing of the neural crest (NC) versus ectodermal contribution to the developing nasal placode was performed using two complementary mouse models, the NC-specific Wnt1Cre mouse line and an ectodermal-specific Crect mouse line. Using these lines we prove that the NC give rise to the olfactory ensheathing cells and subpopulations of GnRH-1 neurons, olfactory and vomeronasal cells. These data demonstrate that Schwann cells and olfactory ensheathing cells share a common developmental origin. Furthermore, the results indicate that certain conditions that impact olfaction and sexual development, such as Kallmann syndrome, may be in part neurocristopathies.
Authors:
Paolo Emanuele Forni; Carol Taylor-Burds; Vida Senkus Melvin; Trevor Williams; Taylor Williams; Susan Wray
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The Journal of neuroscience : the official journal of the Society for Neuroscience     Volume:  31     ISSN:  1529-2401     ISO Abbreviation:  J. Neurosci.     Publication Date:  2011 May 
Date Detail:
Created Date:  2011-05-05     Completed Date:  2011-08-05     Revised Date:  2013-06-30    
Medline Journal Info:
Nlm Unique ID:  8102140     Medline TA:  J Neurosci     Country:  United States    
Other Details:
Languages:  eng     Pagination:  6915-27     Citation Subset:  IM    
Affiliation:
Cellular and Developmental Neurobiology Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland 20892, USA.
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MeSH Terms
Descriptor/Qualifier:
Animals
Cell Count
Cell Lineage / physiology*
Ectoderm / cytology*,  metabolism
Gonadotropin-Releasing Hormone / metabolism*
Immunohistochemistry
Mice
Mice, Transgenic
Neural Crest / cytology*,  metabolism
Neurons / cytology*,  physiology
Schwann Cells / cytology*,  metabolism
Grant Support
ID/Acronym/Agency:
DE12728/DE/NIDCR NIH HHS
Chemical
Reg. No./Substance:
33515-09-2/Gonadotropin-Releasing Hormone
Comments/Corrections
Erratum In:
J Neurosci. 2011 Sep 7;31(36):13023
Note: Williams, Taylor [corrected to Williams, Trevor]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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