Document Detail

Neural Connectivity of the Pedunculopontine Nucleus in Relation to Walking Ability in Chronic Patients with Intracerebral Hemorrhage.
MedLine Citation:
PMID:  22433944     Owner:  NLM     Status:  Publisher    
Objectives: As the mesencephalic locomotor center, the pedunculopontine nucleus (PPN) is known to be involved in control of locomotor function. We investigated neural connectivity of the PPN in relation to walking ability in chronic patients with spontaneous intracerebral hemorrhage. Methods: Forty-three consecutive chronic patients with subcortical hemorrhage and 20 healthy control subjects were recruited. A seed region of interest was manually drawn on the PPN and connectivity of the PPN was measured. Results: In the affected hemisphere, connectivity with the ipsilesional cerebellar locomotor center and connectivity with the contralesional pontine locomotor center were decreased in patients who could not walk, compared with patients who could walk and normal controls (p < 0.05). Conclusions: Connectivity between the PPN and ipsi-lesional cerebellum locomotor center and contralesional pontine locomotor center in the affected hemisphere appears to be related to walking ability.
Sang Seok Yeo; Dong Gyu Lee; Byung Yeon Choi; Chul Hoon Chang; Young Jin Jung; Seong Ho Kim; Min Cheol Chang; Sung Ho Jang
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-3-15
Journal Detail:
Title:  European neurology     Volume:  67     ISSN:  1421-9913     ISO Abbreviation:  -     Publication Date:  2012 Mar 
Date Detail:
Created Date:  2012-3-21     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0150760     Medline TA:  Eur Neurol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  226-231     Citation Subset:  -    
Copyright Information:
Copyright © 2012 S. Karger AG, Basel.
Department of Physical Medicine and Rehabilitation, College of Medicine, Yeungnam University, Taegu, Republic of Korea.
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