| Neural circuits, neurotransmitters, and behavior : serotonin and temperament in bulimic syndromes. | |
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MedLine Citation:
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PMID: 21107929 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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In bulimia nervosa (BN), and in related binge-purge syndromes, factors affecting central serotonin (5-hydroxytryptamine, 5-HT) function appear to contribute not only to appetitive dysregulation but also to temperamental and personality manifestations. Drawing upon findings from neurobiological, molecular-genetic, and brain-imaging studies, we present an integrative model of the role of 5-HT function in bulimic syndromes. At the core of our model is a consideration of the ways in which diverse hereditary and environmental influences impact the action of the 5-HT system. We believe that our model helps account for heterogeneous traits seen in the bulimic population, for disproportionate representation of individuals displaying pathological personality traits and exposure to severe environmental stressors, and for interindividual variations as to treatment response. |
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Authors:
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Howard Steiger; Kenneth R Bruce; Patricia Groleau |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Current topics in behavioral neurosciences Volume: 6 ISSN: 1866-3370 ISO Abbreviation: Curr Top Behav Neurosci Publication Date: 2011 |
Date Detail:
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Created Date: 2011-01-18 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101535383 Medline TA: Curr Top Behav Neurosci Country: Germany |
Other Details:
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Languages: eng Pagination: 125-38 Citation Subset: IM |
Affiliation:
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Eating Disorders Program, Douglas University Institute, 6875 LaSalle Blvd, Montreal (Verdun), QC, Canada, H4H 1R3, stehow@douglas.mcgill.ca. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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