Document Detail

Neural 22-carbon fatty acids in the weanling rat respond rapidly and specifically to a range of dietary linoleic to alpha-linolenic fatty acid ratios.
MedLine Citation:
PMID:  1673995     Owner:  NLM     Status:  MEDLINE    
Changing the dietary ratio of the essential fatty acids (EFA), 18:2n6 and 18:3n3, while keeping the amounts of other fatty acids in the diet constant can rapidly and specifically alter the proportions of n6 and n3 22-carbon fatty acids in the brain of the weanling rat. A dietary 18:2n6/18:3n3 ratio of 165 versus 1.8 caused higher n6 and lower n3 22-carbon fatty acid levels, without changing total 22-carbon fatty acid levels, in phosphatidylethanolamine and phosphatidylcholine from several neural membrane fractions. This was apparent after only 2 weeks and showed no sign of plateauing after 12 weeks. Other neural fatty acids were essentially unaffected. The three most abundant 22-carbon fatty acids responded somewhat differently to increments in the dietary 18:2n6/18:3n3 ratio (1.8, 9, 36, and 165). Levels of 22:4n6 increased by similar absolute amounts for each four-fold increase in dietary 18:2n6/18:3n3 ratio; in contrast, the largest absolute changes in 22:5n6 and 22:6n3 levels occurred as the 18:2n6/18:3n3 ratio increased from 36 to 165. This study shows that the 18:2n6/18:3n3 ratio of diets high in fat (40% of energy) and adequate in EFA, both typical of diets in developed countries, can substantially and relatively quickly affect the 22-carbon fatty acids in the brain, even after the rapid accumulation of these fatty acids during neural growth has ceased.
J R Dyer; C E Greenwood
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of neurochemistry     Volume:  56     ISSN:  0022-3042     ISO Abbreviation:  J. Neurochem.     Publication Date:  1991 Jun 
Date Detail:
Created Date:  1991-06-12     Completed Date:  1991-06-12     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  2985190R     Medline TA:  J Neurochem     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1921-31     Citation Subset:  IM    
Department of Nutritional Sciences, Faculty of Medicine, University of Toronto, Ontario, Canada.
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MeSH Terms
Dietary Fats / pharmacology*
Fatty Acids / chemistry,  metabolism*
Linoleic Acid
Linoleic Acids / pharmacology*
Linolenic Acids / pharmacology*
Nervous System / metabolism*
Rats, Inbred Strains
Time Factors
alpha-Linolenic Acid
Reg. No./Substance:
0/Dietary Fats; 0/Fatty Acids; 0/Linoleic Acids; 0/Linolenic Acids; 2197-37-7/Linoleic Acid; 463-40-1/alpha-Linolenic Acid; 7440-44-0/Carbon

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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