Document Detail


Network motifs provide signatures that characterize metabolism.
MedLine Citation:
PMID:  23287894     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Motifs are repeating patterns that determine the local properties of networks. In this work, we characterized all 3-node motifs using enzyme commission numbers of the International Union of Biochemistry and Molecular Biology to show that motif abundance is related to biochemical function. Further, we present a comparative analysis of motif distributions in the metabolic networks of 21 species across six kingdoms of life. We found the distribution of motif abundances to be similar between species, but unique across cellular organelles. Finally, we show that motifs are able to capture inter-species differences in metabolic networks and that molecular differences between some biological species are reflected by the distribution of motif abundances in metabolic networks.
Authors:
Erin R Shellman; Charles F Burant; Santiago Schnell
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't     Date:  2013-01-04
Journal Detail:
Title:  Molecular bioSystems     Volume:  9     ISSN:  1742-2051     ISO Abbreviation:  Mol Biosyst     Publication Date:  2013 Mar 
Date Detail:
Created Date:  2013-02-05     Completed Date:  2013-07-17     Revised Date:  2014-03-07    
Medline Journal Info:
Nlm Unique ID:  101251620     Medline TA:  Mol Biosyst     Country:  England    
Other Details:
Languages:  eng     Pagination:  352-60     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Animals
Archaeal Proteins / classification,  genetics
Enzymes / classification,  genetics
Escherichia coli / enzymology
Escherichia coli Proteins / classification,  genetics
Evolution, Molecular
Humans
Metabolic Networks and Pathways*
Methanosarcina barkeri / enzymology
Mitochondria / enzymology
Models, Biological
Plant Proteins / classification,  genetics
Plants / enzymology
Saccharomyces cerevisiae / enzymology
Saccharomyces cerevisiae Proteins / classification,  genetics
Grant Support
ID/Acronym/Agency:
P30 DK089503/DK/NIDDK NIH HHS; P30 DK089503/DK/NIDDK NIH HHS; R01 DK079084/DK/NIDDK NIH HHS; R01 DK079084/DK/NIDDK NIH HHS; T32 GM008322/GM/NIGMS NIH HHS; T32 GM008322/GM/NIGMS NIH HHS; U24 DK097153/DK/NIDDK NIH HHS
Chemical
Reg. No./Substance:
0/Archaeal Proteins; 0/Enzymes; 0/Escherichia coli Proteins; 0/Plant Proteins; 0/Saccharomyces cerevisiae Proteins
Comments/Corrections

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