Document Detail

Netrins: versatile extracellular cues with diverse functions.
MedLine Citation:
PMID:  21558366     Owner:  NLM     Status:  MEDLINE    
Netrins are secreted proteins that were first identified as guidance cues, directing cell and axon migration during neural development. Subsequent findings have demonstrated that netrins can influence the formation of multiple tissues, including the vasculature, lung, pancreas, muscle and mammary gland, by mediating cell migration, cell-cell interactions and cell-extracellular matrix adhesion. Recent evidence also implicates the ongoing expression of netrins and netrin receptors in the maintenance of cell-cell organisation in mature tissues. Here, we review the mechanisms involved in netrin signalling in vertebrate and invertebrate systems and discuss the functions of netrin signalling during the development of neural and non-neural tissues.
Karen Lai Wing Sun; James P Correia; Timothy E Kennedy
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  Development (Cambridge, England)     Volume:  138     ISSN:  1477-9129     ISO Abbreviation:  Development     Publication Date:  2011 Jun 
Date Detail:
Created Date:  2011-05-11     Completed Date:  2011-07-21     Revised Date:  2011-08-03    
Medline Journal Info:
Nlm Unique ID:  8701744     Medline TA:  Development     Country:  England    
Other Details:
Languages:  eng     Pagination:  2153-69     Citation Subset:  IM    
Department of Neurology and Neurosurgery, Montreal Neurological Institute, McGill University, Montreal, QC H3A 2B4, Canada.
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MeSH Terms
Axons / physiology
Cell Adhesion
Cell Adhesion Molecules / metabolism
Cell Communication
Cell Differentiation
Cell Movement
Membrane Proteins / metabolism
Nerve Tissue Proteins / chemistry,  metabolism*
Nervous System / embryology,  metabolism
Neurons / physiology
Receptors, Cell Surface / metabolism*
Signal Transduction
Tumor Suppressor Proteins / metabolism
Grant Support
//Canadian Institutes of Health Research
Reg. No./Substance:
0/Cell Adhesion Molecules; 0/DCC protein, human; 0/DSCAM protein, human; 0/Ligands; 0/Membrane Proteins; 0/Nerve Tissue Proteins; 0/Receptors, Cell Surface; 0/Tumor Suppressor Proteins; 0/neogenin; 0/netrin receptors

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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