Document Detail

Netrin signaling breaks the equivalence between two identified zebrafish motoneurons revealing a new role of intermediate targets.
MedLine Citation:
PMID:  22003409     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: We previously showed that equivalence between two identified zebrafish motoneurons is broken by interactions with identified muscle fibers that act as an intermediate target for the axons of these motoneurons. Here we investigate the molecular basis of the signaling interaction between the intermediate target and the motoneurons.
PRINCIPAL FINDINGS: We provide evidence that Netrin 1a is an intermediate target-derived signal that causes two equivalent motoneurons to adopt distinct fates. We show that although these two motoneurons express the same Netrin receptors, their axons respond differently to Netrin 1a encountered at the intermediate target. Furthermore, we demonstrate that when Netrin 1a is knocked down, more distal intermediate targets that express other Netrins can also function to break equivalence between these motoneurons.
SIGNIFICANCE: Our results suggest a new role for intermediate targets in breaking neuronal equivalence. The data we present reveal that signals encountered during axon pathfinding can cause equivalent neurons to adopt distinct fates. Such signals may be key in diversifying a neuronal population and leading to correct circuit formation.
Laura A Hale; Daniel K Fowler; Judith S Eisen
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't     Date:  2011-10-07
Journal Detail:
Title:  PloS one     Volume:  6     ISSN:  1932-6203     ISO Abbreviation:  PLoS ONE     Publication Date:  2011  
Date Detail:
Created Date:  2011-10-17     Completed Date:  2012-02-02     Revised Date:  2013-06-27    
Medline Journal Info:
Nlm Unique ID:  101285081     Medline TA:  PLoS One     Country:  United States    
Other Details:
Languages:  eng     Pagination:  e25841     Citation Subset:  IM    
Institute of Neuroscience, University of Oregon, Eugene, Oregon, United States of America.
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MeSH Terms
Axons / metabolism
Base Sequence
Cell Differentiation
Cell Movement
Cell Survival
Gene Expression Regulation
Gene Knockdown Techniques
Motor Neurons / cytology*,  metabolism*,  physiology
Muscles / metabolism
Nerve Growth Factors / deficiency,  genetics,  metabolism*
Receptors, Cell Surface / metabolism
Synapses / metabolism,  physiology
Tumor Suppressor Proteins / deficiency,  genetics,  metabolism*
Zebrafish / metabolism*,  physiology
Zebrafish Proteins / deficiency,  genetics,  metabolism*
Grant Support
Reg. No./Substance:
0/Nerve Growth Factors; 0/Receptors, Cell Surface; 0/Tumor Suppressor Proteins; 0/Zebrafish Proteins; 0/dcc protein, zebrafish; 0/netrin receptors; 158651-98-0/netrin-1

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