| Netilmicin use in pediatric patients. | |
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MedLine Citation:
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PMID: 7438970 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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40 newborn infants and children were treated with netilmicin. With a 2-mg/kg dose, the average peak serum concentration was 4.4 microgram/ml. Serum concentrations resulting from the first dose were markedly lower than subsequent doses and therapeutically inadequate. Significant drug accumulation did not occur: peak and trough concentrations on days 2 and 7 were the same in patients with normal renal function. The half-life of netilmicin in infants less than 1 week old was 3.8 h in infants older than 1 week. Infants less than 7 days old require a prolonged dose interval (12 h) to adequately clear the administered dose. Recovery of netilmicin in urine ranged from 50 to 100% and correlated with age and duration of treatment. Elimination of netilmicin was prolonged in newborn infants with renal failure and requires dosage adjustment. Transient change in creatinine clearance occurred in 2 patients (4.6%) and ototoxicity was observed on 2 other patients. |
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Authors:
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V Chindasilpa; V Schauf; L R Hamilton; L J Riff |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Developmental pharmacology and therapeutics Volume: 1 ISSN: 0379-8305 ISO Abbreviation: Dev Pharmacol Ther Publication Date: 1980 |
Date Detail:
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Created Date: 1981-02-19 Completed Date: 1981-02-19 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 8003947 Medline TA: Dev Pharmacol Ther Country: SWITZERLAND |
Other Details:
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Languages: eng Pagination: 238-53 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Bacteria / drug effects Bacterial Infections / drug therapy* Child Gentamicins / therapeutic use* Half-Life Hearing / drug effects Humans Infant Infant, Newborn Infant, Newborn, Diseases / drug therapy Netilmicin / metabolism, therapeutic use*, toxicity |
| Chemical | |
Reg. No./Substance:
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0/Gentamicins; 56391-56-1/Netilmicin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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