Document Detail

Netilmicin effect on urinary retinol binding protein (RBP) and N-acetyl-beta-D-glucosaminidase (NAG) in preterm newborns with and without anoxia.
MedLine Citation:
PMID:  11892904     Owner:  NLM     Status:  MEDLINE    
The study aim was to evaluate urinary excretion of Retinol Binding Protein (RBP), compared with urinary excretion of N-acetyl-beta-D-glucosaminidase (NAG), in preterm infants with anoxia and netilmicin treatment. Urinary RBP and NAG were evaluated in 83 preterm newborns divided in 4 groups: 37 healthy preterm newborns (controls); 14 with neonatal anoxia; 16 treated with ampicillin + netilmicin; 16 with neonatal anoxia and treated with ampicillin + netilmicin. RBP was determined by an automated nephelometric technique and NAG by a colorimetric method on 5-h urine samples in the first week of life. Results showed that urinary excretion of RBP (average from first week values) was 1.06+/-0.67 g/mol creatinine (mean +/- SD) in controls, 1.99+/-1.41 in antibiotic-treated newborns, 3.99+/-4.57 in anoxic newborns and 3.75+/-3.48 in anoxic newborns under antibiotic treatment. When gestational age was not considered, a marked effect of anoxia (P<0.001) and a borderline effect of netilmicin (P<0.059) on RBP excretion were detected by ANOVA. However when gestational age was also considered by analysis of covariance, it appeared as the strongest predictor of RBP excretion (P<0.001), while the effect of netilmicin was no longer significant (P=0.181). The effect of anoxia persisted, although less remarkable (P=0.010). Conversely anoxia did not affect urinary NAG excretion, which was rather correlated with gestational age and netilmicin administration. The authors conclude that RBP and NAG urinary excretion may be used to discriminate between neonatal anoxia and netilmicin treatment, respectively as etiologic factors of renal tubular damage in the newborn.
L Cataldi; M Mussap; G Verlato; M Plebani; V Fanos;
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of chemotherapy (Florence, Italy)     Volume:  14     ISSN:  1120-009X     ISO Abbreviation:  J Chemother     Publication Date:  2002 Feb 
Date Detail:
Created Date:  2002-03-14     Completed Date:  2002-08-23     Revised Date:  2009-08-04    
Medline Journal Info:
Nlm Unique ID:  8907348     Medline TA:  J Chemother     Country:  Italy    
Other Details:
Languages:  eng     Pagination:  76-83     Citation Subset:  IM    
Pediatrics Department, University of the Sacred Heart, Rome, Italy.
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MeSH Terms
Acetylglucosaminidase / urine*
Anoxia / blood*
Gentamicins / pharmacology*
Infant, Newborn
Infant, Premature
Netilmicin / pharmacology*
Retinol-Binding Proteins / urine*
Reg. No./Substance:
0/Gentamicins; 0/Retinol-Binding Proteins; 56391-56-1/Netilmicin; EC

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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