Document Detail


Netilmicin 150 mg every 12 hours in systemic infections.
MedLine Citation:
PMID:  6630105     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Most (76%) of the 284 gentamicin-resistant Enterobacteriaceae isolated from patients hospitalised in Eindhoven or its vicinity proved to be sensitive to netilmicin. The sensitivity rate was 96% for amikacin and 97% for cefotaxime. Thirty-four patients with systemic infections and isolation of netilmicin-sensitive Enterobacteriaceae were treated with 150 mg netilmicin intravenously every 12 h. All except one patient reacted favourably. The patient who did not had a netilmicin-sensitive Escherichia coli septicaemia which recurred during treatment. The treatment was well tolerated. No ototoxicity or permanent nephrotoxicity were noted. Although the variation of serum levels was as great for netilmicin as has been reported for other aminoglycosides, they were in general within acceptable limits. In patients with reduced renal function peak levels above 16 mg/l were found five times more frequently than in patients with normal renal function. However, serum levels should also be monitored in patients with normal renal function.
Authors:
M J Haverkorn
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The Journal of antimicrobial chemotherapy     Volume:  12     ISSN:  0305-7453     ISO Abbreviation:  J. Antimicrob. Chemother.     Publication Date:  1983 Sep 
Date Detail:
Created Date:  1983-12-20     Completed Date:  1983-12-20     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  7513617     Medline TA:  J Antimicrob Chemother     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  209-17     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Adult
Aged
Child
Drug Administration Schedule
Drug Resistance, Microbial
Enterobacteriaceae Infections / drug therapy*
Female
Gentamicins / administration & dosage*,  pharmacology
Humans
Male
Middle Aged
Netilmicin / administration & dosage*,  blood
Chemical
Reg. No./Substance:
0/Gentamicins; 56391-56-1/Netilmicin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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