Document Detail


Netherton's syndrome and lepromatous leprosy: a mere coincidence?
MedLine Citation:
PMID:  23347305     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
Objectives  Netherton's syndrome (NS) is a rare autosomal recessive condition, first described in 1958, which involves a complex immunological dysfunction, ichthyosiform dermatitis, and erythroderma, characteristic defects of the hair shaft and atopy. Recurrent bacterial infection in the skin of patients with NS is frequent. Methods  This paper represents the first case report of leprosy and concurrent NS. Discussion  This case merits discussion among doctors in endemic and non-endemic areas to evaluate the chronic use of systemic corticosteroids as a risk factor for leprosy. The present patient came from an endemic area of leprosy and was treated chronically with systemic corticosteroids for erythroderma. This treatment, along with the immunodeficiency related to the syndrome and caused by a genetic mutation in SPINK5, may be a facilitating factor for the infection.
Authors:
Felipe Ladeira de Oliveira; Bruna Obeica Vasconcellos; Thais Schiavo de Morais; Mayara Brito Nascimento; Renata Teles; José Augusto da Costa Nery; Marcos José Sumrell Miranda; Luna Azulay-Abulafia
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  International journal of dermatology     Volume:  52     ISSN:  1365-4632     ISO Abbreviation:  Int. J. Dermatol.     Publication Date:  2013 Feb 
Date Detail:
Created Date:  2013-01-25     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0243704     Medline TA:  Int J Dermatol     Country:  England    
Other Details:
Languages:  eng     Pagination:  186-90     Citation Subset:  IM    
Copyright Information:
© 2013 The International Society of Dermatology.
Affiliation:
Section for Sexually Transmitted Diseases and Leprosy, Professor R. D. Azulay Institute of Dermatology, Hospital Santa Casa da Misericórdia, Rio de Janeiro, RJ, Brazil.
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