Document Detail


The Netherlands Twin Register biobank: a resource for genetic epidemiological studies.
MedLine Citation:
PMID:  20477721     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
In 2004 the Netherlands Twin Register (NTR) started a large scale biological sample collection in twin families to create a resource for genetic studies on health, lifestyle and personality. Between January 2004 and July 2008, adult participants from NTR research projects were invited into the study. During a home visit between 7:00 and 10:00 am, fasting blood and morning urine samples were collected. Fertile women were bled on day 2-4 of the menstrual cycle, or in their pill-free week. Biological samples were collected for DNA isolation, gene expression studies, creation of cell lines and for biomarker assessment. At the time of blood sampling, additional phenotypic information concerning health, medication use, body composition and smoking was collected. Of the participants contacted, 69% participated. Blood and urine samples were collected in 9,530 participants (63% female, average age 44.4 (SD 15.5) years) from 3,477 families. Lipid profile, glucose, insulin, HbA1c, haematology, CRP, fibrinogen, liver enzymes and creatinine have been assessed. Longitudinal survey data on health, personality and lifestyle are currently available for 90% of all participants. Genome-wide SNP data are available for 3,524 participants, with additional genotyping ongoing. The NTR biobank, combined with the extensive phenotypic information available within the NTR, provides a valuable resource for the study of genetic determinants of individual differences in mental and physical health. It offers opportunities for DNA-based and gene expression studies as well as for future metabolomic and proteomic projects.
Authors:
Gonneke Willemsen; Eco J C de Geus; Meike Bartels; C E M Toos van Beijsterveldt; Andy I Brooks; G Frederique Estourgie-van Burk; Douglas A Fugman; Chantal Hoekstra; Jouke-Jan Hottenga; Kees Kluft; Piet Meijer; Grant W Montgomery; Patrizia Rizzu; David Sondervan; August B Smit; Sabine Spijker; H Eka D Suchiman; Jay A Tischfield; Thomas Lehner; P Eline Slagboom; Dorret I Boomsma
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Twin research and human genetics : the official journal of the International Society for Twin Studies     Volume:  13     ISSN:  1832-4274     ISO Abbreviation:  Twin Res Hum Genet     Publication Date:  2010 Jun 
Date Detail:
Created Date:  2010-05-18     Completed Date:  2010-08-13     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101244624     Medline TA:  Twin Res Hum Genet     Country:  Australia    
Other Details:
Languages:  eng     Pagination:  231-45     Citation Subset:  IM    
Affiliation:
Department of Biological Psychology, VU University Amsterdam, Amsterdam, Netherlands. ahm.willemsen@psy.vu.nl
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MeSH Terms
Descriptor/Qualifier:
Adult
Anthropometry
Biological Markers / blood,  urine
Biological Specimen Banks*
Humans
Longitudinal Studies
Molecular Epidemiology / methods*,  statistics & numerical data
Netherlands / epidemiology
Phenotype
Registries
Twin Studies as Topic / statistics & numerical data*
Twins, Dizygotic / blood,  urine
Twins, Monozygotic / blood,  urine
Grant Support
ID/Acronym/Agency:
1RC2MH089951-01/MH/NIMH NIH HHS; R01D0042157-01A//PHS HHS; U24 MH068457-06/MH/NIMH NIH HHS
Chemical
Reg. No./Substance:
0/Biological Markers

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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