Document Detail


Net ultrafiltration in peritoneal dialysis: role of direct fluid absorption into peritoneal tissue.
MedLine Citation:
PMID:  1308680     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
'Net ultrafiltration' in peritoneal dialysis refers to the difference between the osmotically induced ultrafiltration into the peritoneal cavity and the fluid loss from the cavity during dialysis. Recent research has demonstrated that, during a 3- to 4-hour experimental dialysis, 5-25% of the total fluid loss is via lymphatics and the remaining fluid is absorbed directly into the tissue surrounding the peritoneal cavity. The driving force for this convection into tissue is the hydrostatic pressure gradient between the peritoneal cavity and the tissue, which ranges from 2 to 8 mm Hg during the typical 2-liter dialysis in humans. Because the convection from the cavity occurs during periods of a positive net ultrafiltration, the peritoneum and its underlying tissue cannot be represented as a single membrane but function as a composite of 'tight' and 'loose' membranes. More data on the mechanical properties of the peritoneal tissue space and its response to hydrostatic pressure in the cavity are required before we fully understand fluid transport at the tissue level.
Authors:
M F Flessner
Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Blood purification     Volume:  10     ISSN:  0253-5068     ISO Abbreviation:  Blood Purif.     Publication Date:  1992  
Date Detail:
Created Date:  1993-10-14     Completed Date:  1993-10-14     Revised Date:  2005-11-16    
Medline Journal Info:
Nlm Unique ID:  8402040     Medline TA:  Blood Purif     Country:  SWITZERLAND    
Other Details:
Languages:  eng     Pagination:  136-47     Citation Subset:  IM; S    
Affiliation:
Laboratory of Kidney and Electrolyte Metabolism, National Institutes of Health, Bethesda, Md.
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MeSH Terms
Descriptor/Qualifier:
Absorption
Animals
Ascitic Fluid / metabolism*
Biological Transport / physiology
Humans
Peritoneal Cavity / physiology*
Peritoneal Dialysis*
Proteins / metabolism
Ultrafiltration
Chemical
Reg. No./Substance:
0/Proteins

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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