Document Detail

Net-like pattern of calcification on plain soft-tissue radiographs in patients with calciphylaxis.
MedLine Citation:
PMID:  22841657     Owner:  NLM     Status:  Publisher    
BACKGROUND: Calciphylaxis is a rare, life-threatening syndrome marked by vascular calcification and cutaneous necrosis. The role of radiographic imaging in assisting in diagnosis has not been established. OBJECTIVE: To investigate the potential role of plain radiographic imaging in the diagnosis of calciphylaxis. METHODS: We searched for cases of patients at our tertiary referral center with a diagnosis of calciphylaxis between Jan 1, 1996, and Dec 31, 2010. Two control patients receiving dialysis but without calciphylaxis were age- and sex-matched to each study patient. Plain radiographs were obtained from the date closest to diagnosis in patients with calciphylaxis and from matched controls at approximately the same dates. Two radiologists, masked as to cases and controls, read each image together. Size of calcified vessels, pattern and extent of calcifications, presence of net-like or other calcifications, and bone density/mineralization were recorded and analyzed. RESULTS: Twenty-nine patients with calciphylaxis (mean age, 57 years; 21 [72%] women) were identified. Mean age at diagnosis was 57 years (range, 36-75 years). Compared with those of controls, plain radiographs of patients with calciphylaxis had more vascular calcifications, more small-vessel calcifications, and a netlike pattern of calcifications. A netlike pattern of calcifications had considerable strength of association with calciphylaxis (odds ratio, 9.4) and a specificity of nearly 90%. These findings were preserved even if only one image was used per patient. LIMITATIONS: This was a retrospective study. CONCLUSION: A netlike pattern of calcifications on plain radiographs was more common in patients with calciphylaxis and may aid in diagnosis.
Eugenia Shmidt; Naveen S Murthy; John M Knudsen; Roger H Weenig; M Amanda Jacobs; Autumn M Starnes; Mark D P Davis
Related Documents :
22693517 - Spectrum of disorders associated with elevated serum igg4 levels encountered in clinica...
21895727 - Ranolazine reduces ventricular tachycardia burden and icd shocks in patients with drug-...
22533657 - Small pheochromocytomas: significance, diagnosis, and outcome.
22745037 - Association of systemic lupus erythematosus with angiographically defined coronary arte...
22234447 - Complement activation in patients with isolated antiphospholipid antibodies or primary ...
10595477 - The usefulness of tc-99m tetrofosmin scintigraphy in the diagnosis and localization of ...
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-7-27
Journal Detail:
Title:  Journal of the American Academy of Dermatology     Volume:  -     ISSN:  1097-6787     ISO Abbreviation:  -     Publication Date:  2012 Jul 
Date Detail:
Created Date:  2012-7-30     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7907132     Medline TA:  J Am Acad Dermatol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2012 American Academy of Dermatology, Inc. Published by Mosby, Inc. All rights reserved.
Dr Shmidt is a resident in the Department of Internal Medicine, Mayo Clinic, Rochester, Minnesota.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Species tree estimation for a deep phylogenetic divergence in the New World monkeys (Primates: Platy...
Next Document:  Intrathecal dihydroergotamine inhibits capsaicin-induced vasodilatation in the canine external carot...