| Net digestive absorption and adaptive hyperphagia in adult short bowel patients. | |
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MedLine Citation:
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PMID: 15306586 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND AND AIMS: Intestinal adaptation after small bowel resection in humans is debated. We have quantified in adult short bowel (remnant small bowel length <2 m) patients oral intake and net digestive absorption and their evolution over time. PATIENTS AND METHODS: Oral intake and faecal output were studied over three days in 90 patients (39 and 51 without or with parenteral nutrition, respectively) and in 14 patients in early (<6 months) and late (>6 months) periods after digestive continuity. Nitrogen and fat output were measured using chemiluminescence and Van de Kamer techniques, respectively. RESULTS: In the whole group, 81% of patients had hyperphagia (spontaneous oral intake >1.5 x resting energy expenditure), independently and negatively related to fat absorption (p<0.01) and body mass index (p<0.001) but not braked by the presence of parenteral nutrition. Protein and fat absorption were related to small bowel length. We observed, in the late in comparison with the early period after digestive continuity: an increase in oral intake (1.6 v 2.3 resting energy expenditure), decrease in stool weight/oral intake ratio, no reduction in per cent fat absorption, and protein absorption improvement associated with a significant increase in the amount of protein absorbed (40 v 64 g/day; p<0.05), both being correlated with remnant small bowel length (p<0.01). CONCLUSIONS: This study confirms an adaptive hyperphagia in adult short bowel patients. Over time, hyperphagia and amount of protein absorbed increased, the latter being related to remnant small bowel length, indicating a behavioural adaptation that allows expression of intestinal absorptive adaptation. |
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Authors:
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P Crenn; M C Morin; F Joly; S Penven; F Thuillier; B Messing |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Gut Volume: 53 ISSN: 0017-5749 ISO Abbreviation: Gut Publication Date: 2004 Sep |
Date Detail:
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Created Date: 2004-08-12 Completed Date: 2004-10-04 Revised Date: 2009-11-18 |
Medline Journal Info:
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Nlm Unique ID: 2985108R Medline TA: Gut Country: England |
Other Details:
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Languages: eng Pagination: 1279-86 Citation Subset: AIM; IM |
Affiliation:
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Hepatogastroenterology and Nutrition Support Department, Hôpital Lariboisière, 2 rue Ambroise Paré, 75475 Paris Cedex 10, France. pascal.crenn@lrb.ap-hop-paris.fr |
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| MeSH Terms | |
Descriptor/Qualifier:
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Adaptation, Physiological Adult Aged Aged, 80 and over Body Mass Index Defecation Dietary Proteins / pharmacokinetics Eating Energy Intake Female Humans Hyperphagia / physiopathology* Intestinal Absorption* Male Middle Aged Parenteral Nutrition Short Bowel Syndrome / pathology, physiopathology*, therapy |
| Chemical | |
Reg. No./Substance:
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0/Dietary Proteins |
| Comments/Corrections | |
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