| Net acid excretion capacity is related to blood hydrogen ion and serum carbon dioxide. | |
| | |
MedLine Citation:
|
PMID: 19793591 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Acid-base imbalance due to dietary food patterns has emerged as one of the hypotheses leading to modern-day diseases. This study examined if a new method to assess the renal ability to excrete an acid load, that is, the net acid excretion capacity (NAEC), constructed from net acid excretion (NAE) and urine pH, relates to blood hydrogen ion concentration ([H+]) and serum carbon dioxide concentration ([CO2]). In a second analysis, NAE to pH relationship was examined, and is de facto treated to be linear. This study used historical, cross-sectional data of 58 repeated measurements from 8 subjects for the primary measurements of NAEC, blood [H+], and serum [CO2]. Using fixed models, higher NAEC associated with lower [H+] and higher [CO2]. Using hierarchical models, the interindividual variations in [H+] and [CO2] explained the variations in NAEC. In the second analysis (n = 59), a quadratic NAE to pH relationship (NAE = -846.77 + 341.47 pH - 31.50 pH(2)) can be reported. Net acid excretion capacity, a noninvasive tool to assess the renal ability to excrete an acid load, has a physiologic base to it, in that it captures the inherent nonlinear relations of NAE to pH explaining endogenous [H+] retention/excretion. A higher vegetable and fruit consumption might relieve NAEC and allow excess [H+] loss via both renal and respiratory routes. |
| | |
Authors:
|
Shoma Berkemeyer |
Publication Detail:
|
Type: Journal Article Date: 2009-09-29 |
Journal Detail:
|
Title: Metabolism: clinical and experimental Volume: 59 ISSN: 1532-8600 ISO Abbreviation: Metab. Clin. Exp. Publication Date: 2010 Mar |
Date Detail:
|
Created Date: 2010-02-17 Completed Date: 2010-03-15 Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 0375267 Medline TA: Metabolism Country: United States |
Other Details:
|
Languages: eng Pagination: 338-42 Citation Subset: IM |
Copyright Information:
|
(c) 2010 Elsevier Inc. All rights reserved. |
Affiliation:
|
University of Bochum, Department of Geriatrics-Marienhospital Herne, D-44627 Herne, Germany. shoma.berkemeyer@ruhr-uni-bochum.de |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Acid-Base Equilibrium
/
physiology Acids / urine* Carbon Dioxide / blood* Cross-Sectional Studies Humans Hydrogen / blood* Hydrogen-Ion Concentration Longitudinal Studies Models, Statistical Nitrogen / blood Nonlinear Dynamics Regression Analysis |
| Chemical | |
Reg. No./Substance:
|
0/Acids; 124-38-9/Carbon Dioxide; 1333-74-0/Hydrogen; 7727-37-9/Nitrogen |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Therapy adherence issues in Parkinson's disease.
Next Document: 2-Deoxy-d-ribose induces cellular damage by increasing oxidative stress and protein glycation in a p...