| Nesidioblastosis, myelodysplastic syndrome and nodular diabetic glomerulosclerosis in an elderly nondiabetic woman: an autopsy report. | |
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MedLine Citation:
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PMID: 10342345 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Nesidioblastosis as the cause of hyperinsulinaemic hypoglycaemia in an adult is rare. We report here an additional case of nesidioblastosis, which resulted in fatal hyperinsulinaemic hypoglycaemia in a 72-year-old woman with an underlying myelodysplastic syndrome. The diagnosis of nesidioblastosis was established only after post-mortem examination with a careful exclusion of minute insulinoma. To our surprise, the renal pathology disclosed typical diabetic nodular glomerulosclerosis in the same patient who had no previous history of diabetes mellitus (DM). Nesidioblastosis has been reported to cause 'reversal' of Type 1 DM and insulinoma causing 'reversal' of Type 2 disease. We therefore hypothesize that our patient might have had an undiagnosed DM in the past, which resulted in the typical diabetic nodular glomerulosclerosis. The nesidioblastosis caused a 'reversal' of DM and even the ultimate development of hyperinsulinaemic hypoglycaemia. |
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Authors:
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S P Yeh; J S Wang; H Wu; M S Yu; E J Hsueh; Y C Wang |
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Publication Detail:
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Type: Case Reports; Journal Article |
Journal Detail:
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Title: Diabetic medicine : a journal of the British Diabetic Association Volume: 16 ISSN: 0742-3071 ISO Abbreviation: Diabet. Med. Publication Date: 1999 May |
Date Detail:
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Created Date: 1999-07-22 Completed Date: 1999-07-22 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 8500858 Medline TA: Diabet Med Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 437-41 Citation Subset: IM |
Affiliation:
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Department of Internal Medicine, China Medical College Hospital, Taichung, Taiwan. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Aged Autopsy Diabetic Nephropathies / complications*, pathology Diagnosis, Differential Fatal Outcome Female Glomerulosclerosis, Focal Segmental / complications*, pathology Humans Hyperinsulinism / complications*, pathology Insulin / analysis Kidney / pathology Myelodysplastic Syndromes / complications*, pathology Pancreatic Diseases / complications*, pathology |
| Chemical | |
Reg. No./Substance:
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11061-68-0/Insulin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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